Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 8/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752168 | 0.90 | PRKCQ (0.59) | PRKCQLRRK2BRD4JAK2 | |
| SCHEMBL20752081 | 0.89 | PRKCQ (0.59) | PRKCQLRRK2BRD4 | |
| SCHEMBL20752186 | 0.86 | PRKCQ (0.56) | PRKCQLRRK2BRD4JAK2 | |
| SCHEMBL20752181 | 0.85 | LRRK2 (0.62) | PRKCQLRRK2 | |
| SCHEMBL20752144 | 0.85 | PRKCQ (0.55) | PRKCQLRRK2 | |
| SCHEMBL20752152 | 0.81 | LRRK2 (0.61) | LRRK2BRD4JAK2 | |
| SCHEMBL20752239 | 0.81 | LRRK2 (0.55) | LRRK2BRD4JAK2 | |
| SCHEMBL20752079 | 0.81 | PRKCQ (0.51) | PRKCQ | |
| SCHEMBL15769573 | 0.80 | PRKCQ (0.62) | PRKCQBRD4JAK2 | |
| SCHEMBL20752295 | 0.79 | LRRK2 (0.51) | PRKCQLRRK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |