Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 8/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752168 | 0.87 | PRKCQ (0.59) | PRKCQLRRK2 | |
| SCHEMBL20752081 | 0.86 | PRKCQ (0.59) | PRKCQLRRK2 | |
| SCHEMBL20752134 | 0.85 | PRKCQ (0.58) | PRKCQLRRK2 | |
| SCHEMBL20752186 | 0.84 | PRKCQ (0.56) | PRKCQLRRK2 | |
| SCHEMBL3493786 | 0.83 | PRKCQ (0.79) | PRKCQLRRK2CDK1KDRPLK1 | |
| SCHEMBL3496289 | 0.83 | PRKCQ (0.65) | PRKCQLRRK2CDK1KDRPLK1 | |
| SCHEMBL20752181 | 0.83 | LRRK2 (0.62) | PRKCQLRRK2 | |
| SCHEMBL20752300 | 0.82 | SRC (0.56) | LRRK2CDK1KDRPLK1 | |
| SCHEMBL20752241 | 0.82 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL15769567 | 0.80 | PRKCQ (0.60) | PRKCQLRRK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |