Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 7/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | QDPR | P09417 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20754050 | 0.84 | JAK1 (0.48) | JAK1MEN1KMT2AJAK2CYP11B2 | |
| SCHEMBL20744346 | 0.82 | JAK1 (0.55) | JAK1MEN1KMT2AJAK2NAMPT | |
| SCHEMBL22324984 | 0.81 | QDPR (0.47) | TDP1MEN1KMT2AQDPRCYP11B2 | |
| SCHEMBL23865569 | 0.80 | QDPR (0.46) | TDP1QDPRCYP11B2CYP11B1NAMPT | |
| SCHEMBL22328944 | 0.79 | JAK1 (0.51) | JAK1TDP1MEN1KMT2AJAK2 | |
| SCHEMBL20753937 | 0.79 | JAK1 (0.51) | JAK1TDP1MEN1KMT2AJAK2 | |
| SCHEMBL20753874 | 0.78 | CYP11B2 (0.58) | JAK1QDPRCYP11B2NAMPT | |
| SCHEMBL29580862 | 0.78 | CYP11B2 (0.58) | JAK1QDPRCYP11B2NAMPT | |
| SCHEMBL20753995 | 0.78 | JAK1 (0.51) | JAK1MEN1KMT2AJAK2NAMPT | |
| SCHEMBL20753956 | 0.74 | JAK1 (0.52) | JAK1MEN1KMT2AJAK2QDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668853-B1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2021-09-29 | — | — | EP | disclosed |
| US-20200253967-A1 | NOVEL COMPOUNDS | BioVersys AG (CH) | 2020-08-13 | — | — | US | disclosed |
| WO-2019034701-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200253967-A1 | NOVEL COMPOUNDS | FNTB, SDHA, FDPS | JAK1 2904/4885TDP1 3806/4885MEN1 2095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.