SCHEMBL20763533

SCHEMBL20763533

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OC3C(O)[C@H](n4cnc5c(=O)[nH]c(N)nc54)O[C@@H]3COP(=O)(O)OC3C(O)[C@H](n4cnc5c4N=CNC5N)O[C@@H]3COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)[nH]1

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 1/20 0.61
FUT5 Q11128 1/20 0.59
KRAS P01116 4/20 0.58
RNASEL Q05823 5/20 0.58
NT5E P21589 1/20 0.57
P2RY1 P47900 3/20 0.55
P2RY6 Q15077 2/20 0.55
ENPP1 P22413 2/20 0.55
P2RX3 P56373 2/20 0.55
P2RY2 P41231 1/20 0.55
P2RY4 P51582 1/20 0.55
P2RX1 P51575 1/20 0.55
P2RY11 Q96G91 1/20 0.55
P2RX4 Q99571 1/20 0.55
P2RY12 Q9H244 1/20 0.54
DCPS Q96C86 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20763738 0.96 RNASEL (0.57) TGM2FUT5KRASRNASELNT5E
SCHEMBL22678645 0.96 RNASEL (0.57) TGM2FUT5KRASRNASELNT5E
SCHEMBL21163271 0.88 TGM2 (0.77) TGM2FUT5KRASRNASELNT5E
SCHEMBL21163269 0.88 TGM2 (0.77) TGM2FUT5KRASRNASELNT5E
SCHEMBL25567646 0.87 TGM2 (0.69) TGM2FUT5KRASRNASELNT5E
SCHEMBL6512071 0.87 TGM2 (0.69) TGM2FUT5KRASRNASELNT5E
SCHEMBL1533923 0.87 TGM2 (0.69) TGM2FUT5KRASRNASELNT5E
SCHEMBL4011876 0.87 TGM2 (0.69) TGM2FUT5KRASRNASELNT5E
SCHEMBL1533928 0.87 TGM2 (0.69) TGM2FUT5KRASRNASELNT5E
SCHEMBL23176397 0.86 TGM2 (0.70) TGM2FUT5KRASRNASELNT5E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200362382-A1 METHODS OF PREPARING MODIFIED RNA MODERNATX, INC. 2020-11-19 US disclosed
WO-2019036638-A1 METHODS OF PREPARING MODIFIED RNA MODERNATX, INC. (US) 2019-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200362382-A1 METHODS OF PREPARING MODIFIED RNA RNGTT, RNMT, NSUN2 TGM2 3899/4885FUT5 1241/4885KRAS 3120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.