SCHEMBL20764854

SCHEMBL20764854

[CH2]C(O)c1cccc(Br)c1

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.44
TDO2 P48775 1/20 0.44
ALDH1A1 P00352 3/20 0.39
MAPK1 P28482 1/20 0.39
CYP3A4 P08684 3/20 0.39
CYP2D6 P10635 3/20 0.39
SLC6A2 P23975 3/20 0.39
SLC6A4 P31645 3/20 0.39
SLC6A3 Q01959 3/20 0.39
KCNH2 Q12809 1/20 0.39
C1S P09871 1/20 0.38
PARP1 P09874 1/20 0.38
SLC18A3 Q16572 1/20 0.37
SIGMAR1 Q99720 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31476387 0.81 IDO1 (0.47) IDO1TDO2ALDH1A1MAPK1CYP3A4
SCHEMBL5872085 0.81 IDO1 (0.47) IDO1TDO2ALDH1A1MAPK1CYP3A4
SCHEMBL5911692 0.81 CYP3A4 (0.47) IDO1TDO2ALDH1A1MAPK1CYP3A4
SCHEMBL241692 0.81 IDO1 (0.47) IDO1TDO2ALDH1A1MAPK1CYP3A4
SCHEMBL5773097 0.81 CYP3A4 (0.47) IDO1TDO2ALDH1A1MAPK1CYP3A4
SCHEMBL16954053 0.81 ALDH1A1 (0.41) IDO1TDO2ALDH1A1MAPK1CYP3A4
SCHEMBL11042008 0.79 IDO1 (0.46) IDO1TDO2ALDH1A1MAPK1CYP3A4
SCHEMBL27689825 0.79 IDO1 (0.46) IDO1TDO2ALDH1A1MAPK1CYP3A4
SCHEMBL15456282 0.79 IDO1 (0.46) IDO1TDO2ALDH1A1MAPK1CYP3A4
SCHEMBL16962177 0.78 IDO1 (0.46) IDO1TDO2ALDH1A1MAPK1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3672973-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS Innopharm (Shanghai) Ltd. (CN) 2020-07-01 EP claimed
WO-2019037640-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOPHARM (SHANGHAI) LTD (CN) 2019-02-28 WO claimed
EP-3672973-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS Innopharm (Shanghai) Ltd. (CN) 2020-07-01 EP disclosed
WO-2019037640-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOPHARM (SHANGHAI) LTD (CN) 2019-02-28 WO disclosed
CN-103906741-B Aminoalkyl substituted N-thienylbenzamide derivatives ASTELLAS PHARMA INC. (JP) 2016-01-20 CN disclosed
CN-104271571-A Tetrazolinone compound and use thereof SUMITOMO CHEMICAL CO 2015-01-07 CN disclosed
CN-104245689-A Tetrazolinone compounds and its use as pesticides SUMITOMO CHEMICAL CO 2014-12-24 CN disclosed
CN-103906741-A Aminoalkyl substituted N-thienylbenzamide derivatives ASTELLAS PHARMA INC 2014-07-02 CN disclosed
CN-101450934-B Sulfonyl-derivatives as novel inhibitors of histone deacetylase JANSSEN PHARMACEUTICA NV 2012-10-10 CN disclosed
CN-101450934-A Sulfonyl-derivatives as novel inhibitors of histone deacetylase JANSSEN PHARMACEUTICA NV (BE) 2009-06-10 CN disclosed
CN-100491361-C Thiazole derivatives and their use as VAP-1 inhibitors FUJISAWA PHARMACEUTICAL CO (JP) 2009-05-27 CN disclosed
CN-100445276-C Sulfonyl derivatives as histone deacetylase inhibitors JANSSEN PHARMACEUTICA NV (BE) 2008-12-24 CN disclosed
CN-101031555-A Thiazole derivative capable of vap-1 inhibitory activity ASTELLAS PHARMA INC (JP) 2007-09-05 CN disclosed
CN-1780836-A Novel diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors ACTELION PHARMACEUTICALS LTD (CH) 2006-05-31 CN disclosed
CN-1761655-A Thiazole derivatives and their use as VAP-1 inhibitors FUJISAWA PHARMACEUTICAL CO (JP) 2006-04-19 CN disclosed
CN-1642931-A Sulfonyl derivatives as novel histone deacetylase inhibitors JANSSEN PHARMACEUTICA NV (BE) 2005-07-20 CN disclosed