SCHEMBL20764902

SCHEMBL20764902

[CH2]C(O)c1ccc(F)c(Br)c1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.35
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
VCP P55072 1/20 0.33
ADRB1 P08588 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRB3 P13945 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
IDO1 P14902 3/20 0.31
KDM4E B2RXH2 1/20 0.31
DPP4 P27487 1/20 0.31
TDO2 P48775 2/20 0.31
AKT1 P31749 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28835620 0.83 KDM1A (0.35) CES2CES1CYP1A2IDO1
SCHEMBL3709776 0.83 PARP1 (0.36) PARP1CES2CES1VCPADRB1
SCHEMBL1759520 0.80 CES2 (0.50) CES2CES1ADRB1ADRA2AADRB3
SCHEMBL2850794 0.79 UGT2B7 (0.44) PARP1CES2CES1ADRB1ADRA2A
SCHEMBL16957667 0.79 PARP1 (0.40) PARP1VCPCYP1A2CYP2D6CYP2C9
SCHEMBL19028362 0.79 UGT2B7 (0.44) PARP1CES2CES1ADRB1ADRA2A
SCHEMBL8220975 0.79 UGT2B7 (0.44) PARP1CES2CES1ADRB1ADRA2A
SCHEMBL16956476 0.79 ADRB2 (0.36) PARP1VCPADRB1ADRA2AADRB3
SCHEMBL16960030 0.78 VCP (0.35) PARP1VCPKDM4EDPP4
SCHEMBL30362089 0.78 PARP1 (0.34) PARP1CES2CES1VCPADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3672973-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS Innopharm (Shanghai) Ltd. (CN) 2020-07-01 EP claimed
WO-2019037640-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOPHARM (SHANGHAI) LTD (CN) 2019-02-28 WO claimed
EP-3672973-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS Innopharm (Shanghai) Ltd. (CN) 2020-07-01 EP disclosed
WO-2019037640-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOPHARM (SHANGHAI) LTD (CN) 2019-02-28 WO disclosed