SCHEMBL20764909

SCHEMBL20764909

[CH2]C(O)c1cccc(Cl)c1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFD P00746 1/20 0.44
CYP2D6 P10635 2/20 0.35
NFKB1 P19838 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 1/20 0.35
PNMT P11086 1/20 0.35
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
GLA P06280 1/20 0.34
ADRB1 P08588 3/20 0.33
ADRB2 P07550 2/20 0.33
AOC3 Q16853 1/20 0.33
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
KIF11 P52732 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRB3 P13945 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
HIF1A Q16665 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23694656 0.79 CFD (0.47) CFDCYP2D6NFKB1CYP1A2CYP3A4
SCHEMBL29738186 0.79 CFD (0.47) CFDCYP2D6NFKB1CYP1A2CYP3A4
SCHEMBL30399893 0.79 CFD (0.47) CFDCYP2D6NFKB1CYP1A2CYP3A4
SCHEMBL16955642 0.79 CFD (0.47) CFDCYP2D6NFKB1CYP1A2CYP3A4
SCHEMBL19816269 0.79 CFD (0.47) CFDCYP2D6NFKB1CYP1A2CYP3A4
SCHEMBL15771491 0.79 ALDH1A1 (0.41) CFDCYP2D6NFKB1CYP1A2CYP3A4
SCHEMBL16951367 0.79 CFD (0.44) CFDCYP2D6NFKB1CYP1A2CYP3A4
SCHEMBL28045728 0.78 CES2 (0.52) CYP1A2CYP3A4ALDH1A1LMNAADRB1
SCHEMBL3815284 0.78 CASP1 (0.46) CYP2D6NFKB1CYP3A4ALDH1A1LMNA
SCHEMBL1759613 0.78 CASP1 (0.46) CYP2D6NFKB1CYP3A4ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3672973-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS Innopharm (Shanghai) Ltd. (CN) 2020-07-01 EP claimed
WO-2019037640-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOPHARM (SHANGHAI) LTD (CN) 2019-02-28 WO claimed
EP-3672973-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS Innopharm (Shanghai) Ltd. (CN) 2020-07-01 EP disclosed
WO-2019037640-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOPHARM (SHANGHAI) LTD (CN) 2019-02-28 WO disclosed