Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | GHSR | Q92847 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28978287 | 0.82 | RIPK1 (0.81) | MAPK14ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL3842434 | 0.81 | GHSR (0.65) | MAPK14ALDH1A1KDM4ELMNAGHSR | |
| SCHEMBL20765787 | 0.81 | KDM4E (0.58) | MAPK14ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL20765606 | 0.80 | GHSR (0.52) | MAPK14ALDH1A1KDM4EGHSRMAPT | |
| SCHEMBL20765603 | 0.80 | GHSR (0.52) | MAPK14ALDH1A1KDM4EGHSRMAPT | |
| Fluorobenzene SCHEMBL27571890 | 0.80 | MAPK14 (0.69) | MAPK14ALDH1A1KDM4EGHSRMAPT | |
| SCHEMBL20782400 | 0.80 | KDM4E (0.59) | MAPK14ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL20765529 | 0.79 | ALDH1A1 (0.74) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL20765497 | 0.79 | MGLL (0.58) | MAPK14ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL20765456 | 0.78 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038683-A1 | COMPOUNDS TARGETING TANDEM BRCT DOMAINS OF BRCA1, COMPOSITIONS AND METHODS THEREOF | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (IN) | 2019-02-28 | — | — | WO | claimed |