Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20765430 | 0.90 | LMNA (0.54) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL19970750 | 0.83 | MEN1 (0.53) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765818 | 0.83 | ROCK2 (0.49) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765490 | 0.81 | MAPK14 (0.54) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765771 | 0.80 | ALDH1A1 (0.59) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765547 | 0.78 | MAPK14 (0.55) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20774945 | 0.78 | MAPK14 (0.55) | LMNAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20765715 | 0.77 | ALDH1A1 (0.56) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL19970751 | 0.77 | BCHE (0.55) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20765516 | 0.77 | MAPK14 (0.48) | LMNAALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038683-A1 | COMPOUNDS TARGETING TANDEM BRCT DOMAINS OF BRCA1, COMPOSITIONS AND METHODS THEREOF | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (IN) | 2019-02-28 | — | — | WO | claimed |