Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20765549 | 0.90 | MEN1 (0.49) | ROCK2MEN1KMT2ABCHEACHE | |
| SCHEMBL20765843 | 0.83 | LMNA (0.51) | ROCK2MEN1KMT2ABCHEACHE | |
| SCHEMBL20765622 | 0.76 | BCHE (0.46) | ROCK2BCHEACHEALDH1A1SMN1; SMN2 | |
| SCHEMBL20765620 | 0.76 | BCHE (0.46) | ROCK2BCHEACHEALDH1A1SMN1; SMN2 | |
| SCHEMBL2735403 | 0.75 | PDE3B (0.62) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL13293707 | 0.75 | PPARA (0.58) | ROCK2ALDH1A1KDM4EMAPTPPARG | |
| SCHEMBL20765540 | 0.74 | ENPP2 (0.57) | BCHEACHEALDH1A1SMN1; SMN2GAA | |
| SCHEMBL20765718 | 0.72 | ALDH1A1 (0.67) | BCHEACHEALDH1A1MAPTFGFR1 | |
| SCHEMBL20765430 | 0.72 | LMNA (0.54) | ROCK2MEN1KMT2ABCHEACHE | |
| SCHEMBL19970751 | 0.72 | BCHE (0.55) | MEN1KMT2ABCHEACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038683-A1 | COMPOUNDS TARGETING TANDEM BRCT DOMAINS OF BRCA1, COMPOSITIONS AND METHODS THEREOF | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (IN) | 2019-02-28 | — | — | WO | claimed |