Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 20/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20768306 | 1.00 | CTSS (0.54) | CTSS | |
| SCHEMBL20768327 | 0.90 | CTSL (0.44) | CTSS | |
| SCHEMBL20768282 | 0.88 | CTSS (0.53) | CTSS | |
| SCHEMBL20768304 | 0.86 | CTSS (0.51) | CTSS | |
| SCHEMBL19301958 | 0.85 | CTSS (0.54) | CTSS | |
| SCHEMBL29417439 | 0.85 | CTSS (0.54) | CTSS | |
| SCHEMBL20786605 | 0.84 | CTSS (0.35) | CTSS | |
| SCHEMBL20786667 | 0.84 | CTSS (0.35) | CTSS | |
| SCHEMBL29417488 | 0.83 | CTSS (0.76) | CTSS | |
| SCHEMBL696835 | 0.83 | CTSS (0.76) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111574422-A | Phenyl difluoromethyl substituted prolyl compounds | 安斯泰来制药株式会社 | 2020-08-25 | — | — | CN | disclosed |
| CN-110248925-B | Phenyl difluoromethyl substituted prolyl compounds | 安斯泰来制药株式会社 | 2020-07-17 | — | — | CN | disclosed |
| US-20190248738-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-08-15 | — | — | US | disclosed |
| US-20190248738-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-08-15 | — | — | US | disclosed |
| US-10322997-B2 | Phenyldifluoromethyl-substituted prolinamide compound | ASTELLAS PHARMA INC. (JP) | 2019-06-18 | — | — | US | disclosed |
| US-10322997-B2 | Phenyldifluoromethyl-substituted prolinamide compound | ASTELLAS PHARMA INC. (JP) | 2019-06-18 | — | — | US | disclosed |
| US-20190071398-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-03-07 | — | — | US | disclosed |
| US-20190071398-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2019-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190248738-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | CTSV, CTSS, CTSF | CTSS 2/4885 |
| US-10322997-B2 | Phenyldifluoromethyl-substituted prolinamide compound | CTSV, CTSS, CTSF | CTSS 2/4885 |
| US-20190071398-A1 | PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND | CTSS, CTSV, CTSF | CTSS 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.