Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.42 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769732 | 0.88 | AKR1C3 (0.48) | AKR1C3AKR1C2AKR1C4PTGS1PLA2G4A | |
| SCHEMBL20769708 | 0.82 | PLA2G4A (0.53) | AKR1C3AKR1C2AKR1C4PTGS1PLA2G4A | |
| SCHEMBL28365715 | 0.81 | CDC25A (0.53) | PLA2G4AKDM4EALDH1A1LMNAMCL1 | |
| SCHEMBL20769656 | 0.80 | PLA2G4A (0.46) | AKR1C3AKR1C2AKR1C4PTGS1PLA2G4A | |
| SCHEMBL20769687 | 0.80 | PLA2G4A (0.46) | AKR1C3AKR1C2AKR1C4PTGS1PLA2G4A | |
| SCHEMBL6242130 | 0.78 | KMT2A (0.52) | AKR1C3AKR1C2AKR1C4PTGS1KEAP1 | |
| SCHEMBL20769701 | 0.78 | ICMT (0.57) | AKR1C3AKR1C2AKR1C4PTGS1KEAP1 | |
| SCHEMBL20787963 | 0.76 | PDE4B (0.40) | KDM4EALDH1A1LMNAPTGDR2KCNH2 | |
| SCHEMBL28977349 | 0.76 | AKR1C3 (0.58) | AKR1C3AKR1C2AKR1C4PTGS1ABCB1 | |
| SCHEMBL29195368 | 0.74 | AKR1C3 (0.42) | AKR1C3AKR1C2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |