Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 5/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769719 | 0.81 | ALDH1A1 (0.65) | ICMTALDH1A1LMNAAKR1C3AKR1C2 | |
| SCHEMBL3596003 | 0.81 | ICMT (0.46) | ICMTPLK1PTGDR2 | |
| SCHEMBL20769732 | 0.81 | AKR1C3 (0.48) | ALDH1A1LMNAAKR1C3AKR1C2AKR1C4 | |
| SCHEMBL28365640 | 0.81 | PLK1 (0.67) | ICMTALDH1A1LMNAPLK1 | |
| SCHEMBL20769700 | 0.80 | LMNA (0.75) | ICMTALDH1A1LMNAPPARGPPARD | |
| SCHEMBL6242130 | 0.79 | KMT2A (0.52) | ALDH1A1LMNAAKR1C3AKR1C2AKR1C4 | |
| SCHEMBL3588680 | 0.78 | ICMT (0.46) | ICMTALDH1A1PTGDR2 | |
| SCHEMBL20769653 | 0.78 | ALDH1A1 (0.61) | ICMTALDH1A1LMNAAKR1C3AKR1C2 | |
| SCHEMBL20769727 | 0.78 | AKR1C3 (0.48) | ALDH1A1LMNAAKR1C3AKR1C2AKR1C4 | |
| SCHEMBL3585665 | 0.77 | ICMT (0.50) | ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |