Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 3/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.45 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769687 | 1.00 | PLA2G4A (0.46) | PLA2G4ALTB4RMETTL3METTL14AKR1C3 | |
| SCHEMBL20791848 | 0.88 | PLA2G4A (0.46) | PLA2G4ALTB4RMETTL3METTL14AKR1C3 | |
| SCHEMBL20769708 | 0.87 | PLA2G4A (0.53) | PLA2G4ALTB4RMETTL3METTL14AKR1C3 | |
| SCHEMBL20769732 | 0.83 | AKR1C3 (0.48) | PLA2G4ALTB4RMETTL3METTL14AKR1C3 | |
| SCHEMBL20769727 | 0.80 | AKR1C3 (0.48) | PLA2G4ALTB4RMETTL3METTL14AKR1C3 | |
| SCHEMBL20787962 | 0.78 | MET (0.39) | PLA2G4ALTB4RMETTL3METTL14LMNA | |
| SCHEMBL20788555 | 0.75 | ALDH1A1 (0.46) | PLA2G4AAKR1C3AKR1C2ALDH1A1LMNA | |
| SCHEMBL20769651 | 0.74 | ALDH1A1 (0.60) | PLA2G4AALDH1A1LMNACXCL8CYP2C9 | |
| SCHEMBL6242130 | 0.73 | KMT2A (0.52) | AKR1C3AKR1C2ALDH1A1LMNAAKR1C4 | |
| SCHEMBL20769701 | 0.73 | ICMT (0.57) | AKR1C3AKR1C2ALDH1A1LMNAAKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |