Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 5/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aphidicolin SCHEMBL20771749 | 0.91 | LMNA (0.61) | POLA1LMNAHTTRECQLSMN1; SMN2 | |
| Aphidicolin SCHEMBL8763668 | 0.86 | POLA1 (1.00) | POLA1LMNAHTTRECQLSMN1; SMN2 | |
| Aphidicolin SCHEMBL16610406 | 0.86 | POLA1 (1.00) | POLA1LMNAHTTRECQLSMN1; SMN2 | |
| Aphidicolin SCHEMBL14667945 | 0.86 | POLA1 (1.00) | POLA1LMNAHTTRECQLSMN1; SMN2 | |
| Aphidicolin SCHEMBL183956 | 0.86 | POLA1 (1.00) | POLA1LMNAHTTRECQLSMN1; SMN2 | |
| Aphidicolin SCHEMBL2332951 | 0.78 | POLA1 (0.59) | POLA1LMNAHTTRECQLSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29351943 | 0.77 | CYP2C19 (0.98) | POLA1LMNAHTTRECQLSMN1; SMN2 | |
| Aphidicolin SCHEMBL20771139 | 0.76 | POLA1 (0.71) | POLA1LMNAHTTRECQLSMN1; SMN2 | |
| SCHEMBL14552897 | 0.73 | LMNA (0.73) | POLA1LMNAHTTRECQLSMN1; SMN2 | |
| SCHEMBL15747 | 0.71 | CYP2C19 (0.70) | POLA1LMNAHTTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046303-A1 | A METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-07 | — | — | WO | disclosed |