Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 7/20 | 0.48 |
| ▸ | SLC2A3 | P11169 | 7/20 | 0.48 |
| ▸ | SLC2A2 | P11168 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2078604 | 0.92 | KDM4E (0.46) | KDM4EMAPTNPC1RAB9ASLC2A1 | |
| SCHEMBL2303695 | 0.87 | XDH (0.47) | KDM4EMAPTNPC1RAB9ASLC2A1 | |
| SCHEMBL2075111 | 0.85 | SLC2A1 (0.50) | KDM4EMAPTNPC1RAB9ASLC2A1 | |
| SCHEMBL2075107 | 0.82 | ALDH1A1 (0.46) | KDM4EMAPTNPC1RAB9ASLC2A1 | |
| SCHEMBL2077453 | 0.82 | MAPT (0.46) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL2078498 | 0.82 | XDH (0.47) | KDM4EMAPTNPC1RAB9ASLC2A1 | |
| SCHEMBL3780063 | 0.80 | SLC2A1 (0.48) | KDM4EMAPTNPC1RAB9ASLC2A1 | |
| SCHEMBL2077112 | 0.79 | ABL1 (0.38) | SLC2A1SLC2A3SLC2A2EGFRTP53 | |
| SCHEMBL2077088 | 0.78 | ABL1 (0.39) | MAPTSLC2A1SLC2A3SLC2A2LMNA | |
| SCHEMBL2075687 | 0.78 | ABL1 (0.41) | MAPTKMT2ALMNATP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354414-B2 | Substituted bicyclic pyrimidines | CEPHALON, INC (US) | 2013-01-15 | — | — | US | disclosed |
| US-20110053920-A1 | SUBSTITUTED BICYCLIC PYRIMIDINES | CEPHALON, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| US-7851468-B2 | Substituted pyrazolo[3,4-d]pyrimidines | CEPHALON, INC. (US) | 2010-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053920-A1 | SUBSTITUTED BICYCLIC PYRIMIDINES | DPYD, P2RX5, P2RX7 | KDM4E 3148/4885MAPT 620/4885NPC1 2842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.