Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.74 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20774897 | 0.85 | ROCK2 (1.00) | ROCK2ROCK1CCNE1CDK2 | |
| SCHEMBL20774521 | 0.84 | ROCK2 (1.00) | ROCK2ROCK1MAPTLMNAMAPK1 | |
| SCHEMBL20774679 | 0.79 | ROCK2 (0.84) | ROCK2ROCK1 | |
| SCHEMBL30611462 | 0.78 | ROCK2 (0.63) | ROCK2ROCK1POLB | |
| SCHEMBL20774636 | 0.78 | ROCK2 (0.63) | ROCK2ROCK1POLB | |
| SCHEMBL18153383 | 0.76 | ROCK2 (0.68) | ROCK2ROCK1MAPTLMNACCNE1 | |
| SCHEMBL18063516 | 0.74 | LMNA (0.72) | ROCK2ROCK1MAPTLMNACCNE1 | |
| SCHEMBL20774886 | 0.73 | ROCK2 (0.78) | ROCK2ROCK1 | |
| SCHEMBL22126118 | 0.73 | ROCK2 (0.78) | ROCK2ROCK1 | |
| SCHEMBL25630333 | 0.72 | ROCK2 (0.78) | ROCK2ROCK1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111587112-B | Rho-related inhibitors of coiled-coil-containing protein kinases | 卡德门企业有限公司 | 2023-10-10 | — | — | CN | disclosed |
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC (US) | 2023-06-08 | — | — | US | disclosed |
| US-11613531-B2 | Inhibitors of RHO associated coiled-coil containing protein kinase | KADMON CORPORATION, LLC (US) | 2023-03-28 | — | — | US | disclosed |
| CN-111587112-A | Rho-related inhibitors of coiled coil protein kinase | 卡德门企业有限公司 | 2020-08-25 | — | — | CN | disclosed |
| EP-3675861-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | Kadmon Corporation, LLC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-20200199109-A1 | Inhibitors of RHO Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC | 2020-06-25 | — | — | US | disclosed |
| US-20200199109-A1 | Inhibitors of RHO Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC | 2020-06-25 | — | — | US | disclosed |
| WO-2019045824-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON CORPORATION, LLC (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2019045824-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON CORPORATION, LLC (US) | 2019-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885MAPT 282/4885 |
| US-20200199109-A1 | Inhibitors of RHO Associated Coiled-Coil Containing Protein Kinase | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885MAPT 282/4885 |
| US-11613531-B2 | Inhibitors of RHO associated coiled-coil containing protein kinase | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885MAPT 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.