Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 2/20 | 0.58 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 5/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20782358 | 0.99 | BRPF1 (0.60) | BRPF1SYKABL1BRD4BRAF | |
| SCHEMBL22126774 | 0.97 | BRPF1 (0.55) | BRPF1SYKABL1BRD4BRAF | |
| SCHEMBL20769912 | 0.95 | BRPF1 (0.57) | BRPF1SYKBRD4BRAFEML4 | |
| SCHEMBL20769998 | 0.86 | BRPF1 (0.49) | BRPF1SYKBRD4BRAFEML4 | |
| SCHEMBL31039593 | 0.81 | MEN1 (0.42) | BRPF1SYKBRD4BRAFEML4 | |
| SCHEMBL20771719 | 0.81 | MEN1 (0.42) | BRPF1SYKBRD4BRAFEML4 | |
| SCHEMBL22126773 | 0.79 | ALDH1A1 (0.53) | BRPF1BRD4NAMPTTRPV1CREBBP | |
| SCHEMBL19260071 | 0.78 | CA1 (0.49) | BRPF1BRD4EML4ALKNAMPT | |
| SCHEMBL18424298 | 0.78 | BRPF1 (0.56) | BRPF1BRD4NAMPTTRPV1CREBBP | |
| SCHEMBL20769933 | 0.77 | FKBP1A (0.53) | BRD4TRPV1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3676255-B1 | THERAPEUTIC INDAZOLES | RUTGERS THE STATE UNIV UNIV OF NEW JERSEY (US) | 2025-04-16 | — | — | EP | disclosed |
| US-12060330-B2 | Therapeutic indazoles | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-08-13 | — | — | US | disclosed |
| US-20220144781-A1 | THERAPEUTIC INDAZOLES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2022-05-12 | — | — | US | disclosed |
| US-11186549-B2 | Therapeutic indazoles | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2021-11-30 | — | — | US | disclosed |
| EP-3676255-A1 | THERAPEUTIC INDAZOLES | Rutgers, The State University University Of New Jersey (US) | 2020-07-08 | — | — | EP | disclosed |
| US-20200199076-A1 | THERAPEUTIC INDAZOLES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2020-06-25 | — | — | US | disclosed |
| WO-2019046467-A1 | THERAPEUTIC INDAZOLES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2019-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12060330-B2 | Therapeutic indazoles | RIF1, QTRT1, NQO2 | BRPF1 1472/4885SYK 1790/4885ABL1 25/4885 |
| US-20220144781-A1 | THERAPEUTIC INDAZOLES | RIF1, QTRT1, NQO2 | BRPF1 1472/4885SYK 1790/4885ABL1 25/4885 |
| US-20200199076-A1 | THERAPEUTIC INDAZOLES | RIF1, NQO2, QTRT1 | BRPF1 1554/4885SYK 1676/4885ABL1 12/4885 |
| US-11186549-B2 | Therapeutic indazoles | RIF1, NQO2, QTRT1 | BRPF1 1554/4885SYK 1676/4885ABL1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.