Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.64 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | CNR1 | P21554 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MTTP | P55157 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20777191 | 1.00 | F10 (0.64) | F10PRSS1RAB9ANPC1CNR1 | |
| SCHEMBL20777203 | 0.83 | NAMPT (0.51) | F10PRSS1RAB9ACNR1CTSL | |
| SCHEMBL22802202 | 0.83 | NAMPT (0.51) | F10PRSS1RAB9ACNR1CTSL | |
| SCHEMBL22822786 | 0.81 | NPC1 (0.48) | F10PRSS1RAB9ANPC1CNR1 | |
| SCHEMBL20777169 | 0.81 | CTSL (0.49) | RAB9ANPC1CNR1CTSLCTSS | |
| SCHEMBL22822802 | 0.80 | NPC1 (0.55) | RAB9ANPC1KDM4ECTSLCTSS | |
| SCHEMBL20777212 | 0.80 | NPC1 (0.55) | RAB9ANPC1KDM4ECTSLCTSS | |
| SCHEMBL22822687 | 0.78 | RAB9A (0.45) | F10PRSS1RAB9ANPC1CNR1 | |
| SCHEMBL2244001 | 0.74 | CCKBR (0.54) | KDM4EMAPTHTT | |
| SCHEMBL20777202 | 0.71 | CTSL (0.52) | CNR1KDM4ECTSLCTSSMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040463-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | PLEX PHARMACEUTICALS, INC. (US) | 2019-02-28 | — | — | WO | disclosed |