Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | KRAS | P01116 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20787985 | 0.85 | KCNA3 (0.48) | KCNA3P2RX7FADS1CTSDEED | |
| SCHEMBL20769734 | 0.78 | KCNA3 (0.46) | KCNA3CNR2SLC5A2PTGDR2 | |
| SCHEMBL1003810 | 0.63 | ADRA1D (0.47) | P2RX7 | |
| SCHEMBL1004033 | 0.63 | ADRA1D (0.47) | P2RX7 | |
| SCHEMBL1003289 | 0.63 | ADRA1D (0.47) | P2RX7 | |
| SCHEMBL4472221 | 0.61 | CTSD (0.37) | P2RX7CTSDCHRNA7CYP11B2GPR84 | |
| SCHEMBL8613906 | 0.61 | CHRNA7 (0.40) | KCNA3P2RX7CHRNA7CYP11B2GPR84 | |
| SCHEMBL8189290 | 0.60 | CHRNA7 (0.49) | P2RX7CHRNA7CYP11B2SIGMAR1GPR84 | |
| SCHEMBL6055981 | 0.60 | FADS1 (0.45) | FADS1CYP11B2SIGMAR1PRCPKDM1A | |
| SCHEMBL6390037 | 0.60 | HTR2A (0.52) | FADS1CTSDPRCPKDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |