Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 2/20 | 0.77 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CASP6 | P55212 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589663 | 0.88 | CTSB (1.00) | CTSBARTDP1MEN1KMT2A | |
| Benzoic Acid SCHEMBL23212127 | 0.82 | TSHR (0.67) | MEN1KMT2AMAPTKDM4EPTGS2 | |
| Methoxymethane SCHEMBL7777573 | 0.81 | CTSB (0.86) | CTSBAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL27913796 | 0.81 | CASP6 (0.62) | CTSBAKR1C4AKR1C3AKR1C2AKR1C1 | |
| Benzoic Acid SCHEMBL27723585 | 0.79 | GPR35 (0.49) | CTSBAKR1C4AKR1C3AKR1C2AKR1C1 | |
| Benzoic Acid SCHEMBL28359564 | 0.79 | CASP6 (0.64) | LMNACASP6ALDH1A1SMN1; SMN2TSHR | |
| Benzoic Acid SCHEMBL27557364 | 0.79 | CASP6 (0.62) | TDP1MEN1KMT2ALMNACASP6 | |
| Benzoic Acid SCHEMBL28772982 | 0.78 | CASP6 (0.53) | TDP1MEN1KMT2ALMNACASP6 | |
| SCHEMBL2769398 | 0.77 | CTSB (0.78) | CTSBTDP1MEN1KMT2ALMNA | |
| Benzoic Acid SCHEMBL23212125 | 0.77 | NAPRT (0.64) | MEN1KMT2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10385013-B2 | Micro/nano materials, products obtained by covalently modifying surface of micro/nano materials with hydrophilic materials, and method for making same | CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD. (CN) | 2019-08-20 | — | — | US | disclosed |
| EP-3470443-A1 | MICRO/NANOMATERIAL, PRODUCT THEREOF WITH SURFACE COVALENTLY MODIFIED WITH HYDROPHILIC MATERIAL, AND MANUFACTURING METHOD | Chongqing Bolanying (BLY) Biotechnology Co., Ltd., China (CN) | 2019-04-17 | — | — | EP | disclosed |
| US-20190077746-A1 | MICRO/NANO MATERIALS, PRODUCTS OBTAINED BY COVALENTLY MODIFYING SURFACE OF MICRO/NANO MATERIALS WITH HYDROPHILIC MATERIALS, AND METHOD FOR MAKING SAME | CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD. (CN) | 2019-03-14 | — | — | US | disclosed |
| CN-106519147-B | The product and preparation method of micro Nano material, its surface hydrophilic substance covalent modification | 重庆博蓝鹰生物技术有限公司 | 2017-10-17 | — | — | CN | disclosed |
| CN-106519147-A | Micro-nano material, product of covalent modification of hydrophilic substances for surface of micro-nano material, and preparation method | 重庆博蓝鹰生物技术有限公司 | 2017-03-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077746-A1 | MICRO/NANO MATERIALS, PRODUCTS OBTAINED BY COVALENTLY MODIFYING SURFACE OF MICRO/NANO MATERIALS WITH HYDROPHILIC MATERIALS, AND METHOD FOR MAKING SAME | PHOSPHO1, PTMS, PAM | CTSB 545/4885AKR1C4 4058/4885AKR1C3 3584/4885 |
| US-10385013-B2 | Micro/nano materials, products obtained by covalently modifying surface of micro/nano materials with hydrophilic materials, and method for making same | PHOSPHO1, PTMS, PAM | CTSB 545/4885AKR1C4 4058/4885AKR1C3 3584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.