Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.54 |
| ▸ | RAB9A | P51151 | 11/20 | 0.54 |
| ▸ | LMNA | P02545 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | STAT1 | P42224 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20791870 | 0.84 | NPC1 (0.74) | NPC1RAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL20787904 | 0.84 | NPC1 (0.74) | NPC1RAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL20791867 | 0.83 | ALDH1A1 (0.75) | NPC1RAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL20788800 | 0.78 | HDAC6 (0.53) | NPC1RAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL20787907 | 0.78 | NPC1 (0.56) | NPC1RAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL20788797 | 0.75 | HDAC6 (0.49) | NPC1RAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL28533972 | 0.74 | PNMT (0.70) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL977061 | 0.72 | PNMT (0.70) | NPC1RAB9AALDH1A1KDM4ENPSR1 | |
| SCHEMBL20787900 | 0.72 | NPC1 (0.63) | NPC1RAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL19086177 | 0.72 | PNMT (0.58) | NPC1RAB9ALMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |