Sugi Predict

Sugi Predict / Compounds / SCHEMBL977061

SCHEMBL977061

SCHEMBL977061

COC(=O)c1cc2c(s1)CCNC2

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PNMT P11086 4/20 0.70
▸ KDM4E B2RXH2 4/20 0.56
▸ HPGD P15428 4/20 0.56
▸ RAB9A P51151 3/20 0.56
▸ MAPK1 P28482 2/20 0.56
▸ NPC1 O15118 1/20 0.56
▸ SMN1; SMN2 Q16637 1/20 0.56
▸ TPSAB1 Q15661 1/20 0.49
▸ TPSD1 Q9BZJ3 1/20 0.49
▸ TPSG1 Q9NRR2 1/20 0.49
▸ ITGB3 P05106 5/20 0.48
▸ ITGA2B P08514 5/20 0.48
▸ ALDH1A1 P00352 4/20 0.46
▸ L3MBTL1 Q9Y468 3/20 0.46
▸ CHRM3 P20309 1/20 0.44
▸ MAPT P10636 2/20 0.43
▸ GLA P06280 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ ATM Q13315 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6421343 0.98 PNMT (0.68) PNMTKDM4EHPGDRAB9AMAPK1
SCHEMBL3304064 0.89 PNMT (0.55) PNMTKDM4EHPGDRAB9AMAPK1
SCHEMBL1173814 0.88 KDM4E (0.56) PNMTKDM4EHPGDRAB9AMAPK1
Hydrochloric Acid SCHEMBL27077216 0.87 KDM4E (0.55) PNMTKDM4EHPGDRAB9AMAPK1
SCHEMBL1175208 0.86 KDM4E (0.60) PNMTKDM4EHPGDRAB9AMAPK1
SCHEMBL1174225 0.84 PNMT (0.65) PNMTKDM4EHPGDMAPK1TPSAB1
SCHEMBL977949 0.84 PNMT (0.73) PNMTTPSAB1TPSD1TPSG1ITGB3
Hydrochloric Acid SCHEMBL3441470 0.83 PNMT (0.71) PNMTTPSAB1TPSD1TPSG1ITGB3
SCHEMBL2761783 0.82 KDM4E (0.54) PNMTKDM4EHPGDRAB9AMAPK1
SCHEMBL16396237 0.82 HDAC6 (0.50) PNMTKDM4EHPGDRAB9AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ONO PHARMACEUTICAL CO., LTD. (JP) 2026-04-14 — — US disclosed
US-20240270755-A1 SUBSTITUTED CYCLOPENTA[c]PYRROLES AS ABHD6 ANTAGONISTS ONO PHARMACEUTICAL CO., LTD. (JP) 2024-08-15 — — US disclosed
US-11981682-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ONO PHARMACEUTICAL CO., LTD. (JP) 2024-05-14 — — US disclosed
EP-4317153-A1 ABHD6 ANTAGONIST ONO Pharmaceutical Co., Ltd. (JP) 2024-02-07 — — EP disclosed
US-20240010658-A1 ABHD6 ANTAGONIST ONO PHARMACEUTICAL CO., LTD. (JP) 2024-01-11 — — US disclosed
CN-117120435-A ABHD6 antagonists 小野药品工业株式会社 2023-11-24 — — CN disclosed
WO-2022211060-A1 ABHD6 ANTAGONIST 小野薬品工業株式会社 2022-10-06 — — WO disclosed
US-10562912-B2 Heterocyclic derivatives and use thereof C&C RESEARCH LABORATORIES (KR) 2020-02-18 — — US disclosed
EP-3004057-B1 HETEROCYCLIC DERIVATIVES AND THEIR USE AS STAT 3 INHIBITORS C&C RES LAB (KR) 2018-07-25 — — EP disclosed
US-20160108056-A1 HETEROCYCLIC DERIVATIVES AND USE THEREOF C&C RESEARCH LABORATORIES (KR) 2016-04-21 — — US disclosed
EP-2197552-B1 NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS 4SC AG (DE) 2012-11-21 — — EP disclosed
US-20110021494-A1 NOVEL TETRAHYDRO-FUSED PYRIDINES AS HISTONE DEACETYLASE INHIBITORS 4SC AG (DE) 2011-01-27 — — US disclosed
US-20110021494-A1 NOVEL TETRAHYDRO-FUSED PYRIDINES AS HISTONE DEACETYLASE INHIBITORS 4SC AG (DE) 2011-01-27 — — US disclosed
US-20110021494-A1 NOVEL TETRAHYDRO-FUSED PYRIDINES AS HISTONE DEACETYLASE INHIBITORS 4SC AG (DE) 2011-01-27 — — US disclosed
EP-2197552-A2 NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS 4SC AG (DE) 2010-06-23 — — EP disclosed
WO-2009037001-A2 NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS 4SC AG (DE) 2009-03-26 — — WO disclosed
WO-2009037001-A2 NOVEL TETRAHYDROFUSEDPYRIDINES AS HISTONE DEACETYLASE INHIBITORS 4SC AG (DE) 2009-03-26 — — WO disclosed
EP-1057814-B1 TETRAHYDROBENZINDOLE DERIVATIVES MEIJI SEIKA KAISHA (JP) 2005-03-09 — — EP disclosed
US-6498251-B1 Tetrahydrobenzindole derivatives MEIJI SEIKA KAISHA, LTD. (JP) 2002-12-24 — — US disclosed
EP-1057814-A1 TETRAHYDROBENZINDOLE DERIVATIVES Meiji Seika Kaisha, Ltd. (JP) 2000-12-06 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240010658-A1 ABHD6 ANTAGONIST ABHD6, ABHD16A, ABHD12 PNMT 1661/4885KDM4E 1105/4885HPGD 2456/4885
US-20110021494-A1 NOVEL TETRAHYDRO-FUSED PYRIDINES AS HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC11, HDAC3 PNMT 3398/4885KDM4E 49/4885HPGD 289/4885
US-20160108056-A1 HETEROCYCLIC DERIVATIVES AND USE THEREOF STAT3, JAK2, STAT5A PNMT 4452/4885KDM4E 3676/4885HPGD 785/4885
US-20240270755-A1 SUBSTITUTED CYCLOPENTA[c]PYRROLES AS ABHD6 ANTAGONISTS ABHD6, ABHD16A, PITHD1 PNMT 1220/4885KDM4E 1018/4885HPGD 1371/4885
US-10562912-B2 Heterocyclic derivatives and use thereof STAT3, JAK2, STAT5A PNMT 4452/4885KDM4E 3676/4885HPGD 785/4885
US-11981682-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ABHD6, ABHD16A, PITHD1 PNMT 1247/4885KDM4E 1038/4885HPGD 1368/4885
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ABHD6, ABHD16A, HDHD5 PNMT 2843/4885KDM4E 1505/4885HPGD 2484/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.