Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | ANPEP | P15144 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | LAP3 | P28838 | 3/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24931234 | 1.00 | EPHX1 (0.56) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL433275 | 1.00 | EPHX1 (0.56) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| Hydrochloric Acid SCHEMBL3805711 | 0.98 | EPHX1 (0.54) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| Hydrochloric Acid SCHEMBL3805714 | 0.98 | EPHX1 (0.54) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| Water SCHEMBL3478299 | 0.98 | EPHX1 (0.54) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| Phenethylamine SCHEMBL8068648 | 0.89 | TAAR1 (0.57) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL20329452 | 0.88 | TAAR1 (0.47) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL902538 | 0.81 | EPHX1 (0.61) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL2736329 | 0.81 | EPHX1 (0.61) | EPHX1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL7307677 | 0.81 | EPHX1 (0.61) | EPHX1SLC6A2TAAR1MAOASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106905264-B | A method of synthesis A Zhalawei intermediate | 连云港杰瑞药业有限公司 | 2019-06-07 | — | — | CN | claimed |
| CN-106905264-A | A kind of method of synthesis A Zhalawei intermediates | 连云港杰瑞药业有限公司 | 2017-06-30 | — | — | CN | claimed |
| JP-7247246-A | — | — | None | — | — | JP | disclosed |
| US-10583137-B2 | Triazole DAGLα inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-03-10 | — | — | US | disclosed |
| CN-106905264-B | A method of synthesis A Zhalawei intermediate | 连云港杰瑞药业有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-106905264-B | A method of synthesis A Zhalawei intermediate | 连云港杰瑞药业有限公司 | 2019-06-07 | — | — | CN | disclosed |
| US-20180344729-A1 | TRIAZOLE DAGLAlpha INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE | 2018-12-06 | — | — | US | disclosed |
| CN-106905264-A | A kind of method of synthesis A Zhalawei intermediates | 连云港杰瑞药业有限公司 | 2017-06-30 | — | — | CN | disclosed |
| WO-2017096315-A1 | TRIAZOLE DAGL(α) INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-06-08 | — | — | WO | disclosed |
| WO-2017096315-A1 | TRIAZOLE DAGL(α) INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-06-08 | — | — | WO | disclosed |
| US-20130116457-A1 | CLEAN, HIGH-YIELD PREPARATION OF S,S AND R,S AMINO ACID ISOSTERES | AEROJET FINE CHEMICALS LLC (US) | 2013-05-09 | — | — | US | disclosed |
| WO-1992006992-A2 | NEW PROCESS FOR BIOPHOSPHORYLATING ORGANIC COMPOUNDS | MERCK & CO., INC. (US) | 1992-04-30 | — | — | WO | disclosed |
| EP-0482797-A1 | Inhibitors of HIV protease | MERCK & CO. INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0480711-A1 | Inhibitors of HIV protease | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| EP-0480624-A1 | Inhibitors of HIV protease | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| EP-0472077-A2 | Phosphonate containing hydroxyethylamin- and norstatin-type pseudopeptides | BAYER AG (DE) | 1992-02-26 | — | — | EP | disclosed |
| CN-1053607-A | The human immunity that is used for the treatment of AIDS lacks the inhibitor of virus protease | MERCK & CO INC (US) | 1991-08-07 | — | — | CN | disclosed |
| EP-0434365-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1991-06-26 | — | — | EP | disclosed |
| EP-0356223-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1990-02-28 | — | — | EP | disclosed |
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10583137-B2 | Triazole DAGLα inhibitors | DAGLB, DAGLA, DGKB | EPHX1 574/4885SLC6A2 4617/4885TAAR1 1033/4885 |
| US-20130116457-A1 | CLEAN, HIGH-YIELD PREPARATION OF S,S AND R,S AMINO ACID ISOSTERES | SRMS, HCK, BHMT2 | EPHX1 45/4885SLC6A2 3986/4885TAAR1 2357/4885 |
| US-20180344729-A1 | TRIAZOLE DAGLAlpha INHIBITORS | DAGLB, DAGLA, DGKB | EPHX1 553/4885SLC6A2 4663/4885TAAR1 1348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.