Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.57 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23686844 | 0.88 | CHRM1 (0.44) | CHRM1SLC6A2SLC6A4BCHEACHE | |
| SCHEMBL20794929 | 0.86 | ACHE (0.50) | CHRM1SLC6A2SLC6A4BCHEACHE | |
| SCHEMBL7460731 | 0.84 | CARM1 (0.52) | CHRM1SLC6A2SLC6A4BCHEACHE | |
| SCHEMBL20766080 | 0.83 | BCHE (0.47) | BCHEACHEBACE1SIGMAR1MEN1 | |
| SCHEMBL22361695 | 0.80 | BCHE (0.52) | CHRM1SLC6A2SLC6A4BCHEACHE | |
| SCHEMBL20778728 | 0.80 | BCHE (0.52) | CHRM1SLC6A2SLC6A4BCHEACHE | |
| SCHEMBL20778729 | 0.80 | BCHE (0.52) | CHRM1SLC6A2SLC6A4BCHEACHE | |
| SCHEMBL22361696 | 0.80 | BCHE (0.52) | CHRM1SLC6A2SLC6A4BCHEACHE | |
| SCHEMBL20794911 | 0.78 | MEN1 (0.48) | BCHEACHEBACE1SIGMAR1MEN1 | |
| SCHEMBL8396136 | 0.78 | HTR3E (0.51) | CHRM1BCHEACHEBACE1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040106-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |