Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 2/20 | 0.50 |
| ▸ | FABP6 | P51161 | 1/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460731 | 0.94 | CARM1 (0.52) | TACR1FABP6CARM1PRMT6ACHE | |
| SCHEMBL13585385 | 0.83 | CARM1 (0.56) | HTR3EHTR3BCHRM4CHRM5CHRNB2 | |
| SCHEMBL8399398 | 0.82 | KMT2A (0.51) | HTR3ASIGMAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL20794929 | 0.79 | ACHE (0.50) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL20794844 | 0.78 | CHRM1 (0.57) | HRH1HTR3ASIGMAR1ACHEBACE1 | |
| SCHEMBL14388279 | 0.78 | ACHE (0.49) | TACR1FABP6CARM1PRMT6ACHE | |
| SCHEMBL13280563 | 0.78 | GRIN2B (0.59) | FABP6CARM1PRMT6ACHEBACE1 | |
| SCHEMBL16254267 | 0.78 | GRIN2B (0.59) | FABP6CARM1PRMT6ACHEBACE1 | |
| SCHEMBL2954218 | 0.77 | GRIN2B (0.69) | FABP6CARM1PRMT6ACHEBACE1 | |
| SCHEMBL4173336 | 0.77 | GRIN2B (0.69) | FABP6CARM1PRMT6ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748321-B1 | PROCESS FOR THE PREPARATION OF AN INDAZOLE-3-CARBOXAMIDE DERIVATIVE | SMITHKLINE BEECHAM PLC (GB) | 1999-06-09 | — | — | EP | disclosed |
| EP-0748321-A1 | PROCESS FOR THE PREPARATION OF AN INDAZOLE-3-CARBOXAMIDE DERIVATIVE | SMITHKLINE BEECHAM PLC (GB) | 1996-12-18 | — | — | EP | disclosed |
| WO-1995023799-A1 | PROCESS FOR THE PREPARATION OF AN INDAZOLE-3-CARBOXAMIDE DERIVATIVE | SMITHKLINE BEECHAM PLC (GB) | 1995-09-08 | — | — | WO | disclosed |