Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.56 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.54 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28366930 | 1.00 | CHRNB4 (0.56) | CHRNB4CHRNA3PDCD1LG2CD274MEN1 | |
| SCHEMBL20795353 | 1.00 | CHRNB4 (0.56) | CHRNB4CHRNA3PDCD1LG2CD274MEN1 | |
| SCHEMBL21491451 | 0.82 | HTR1A (0.41) | CHRNB4CHRNA3PDCD1LG2CD274HTR1A | |
| SCHEMBL11288607 | 0.80 | CHRNB2 (0.52) | MEN1KMT2ACHRNB2CHRNA4CHRNA7 | |
| Hydrochloric Acid SCHEMBL28094487 | 0.78 | CHRNB2 (0.51) | MEN1KMT2ACHRNB2CHRNA4CHRNA7 | |
| SCHEMBL2322690 | 0.78 | MEN1 (0.51) | CHRNB4CHRNA3PDCD1LG2CD274MEN1 | |
| SCHEMBL23373178 | 0.76 | CHRNB2 (0.50) | MEN1KMT2ACHRNB2CHRNA4CHRNA7 | |
| SCHEMBL11277050 | 0.76 | CHRNB2 (0.46) | CHRNB4CHRNA3MEN1KMT2ACHRNB2 | |
| SCHEMBL29527086 | 0.76 | HTR1A (0.55) | CHRNB4CHRNA3HTR1ASLC6A2SLC6A4 | |
| SCHEMBL20178303 | 0.76 | HTR1A (0.55) | CHRNB4CHRNA3HTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3674307-B1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2023-06-07 | — | — | EP | disclosed |
| EP-3674307-B1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2023-06-07 | — | — | EP | disclosed |
| CN-113735881-A | Macrocyclic compounds containing aminopyrazolopyrimidines, pharmaceutical compositions and uses thereof | 正大天晴药业集团股份有限公司 | 2021-12-03 | — | — | CN | disclosed |
| CN-110945000-B | Macrocyclic compounds containing aminopyrazolopyrimidines, pharmaceutical compositions and uses thereof | 正大天晴药业集团股份有限公司 | 2021-09-03 | — | — | CN | disclosed |
| US-20200291042-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. (CN) | 2020-09-17 | — | — | US | disclosed |
| US-20200291042-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. (CN) | 2020-09-17 | — | — | US | disclosed |
| EP-3674307-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2020-07-01 | — | — | EP | disclosed |
| EP-3674307-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2020-07-01 | — | — | EP | disclosed |
| CN-110945000-A | Macrocyclic compounds containing aminopyrazolopyrimidines, pharmaceutical compositions and uses thereof | 正大天晴药业集团股份有限公司 | 2020-03-31 | — | — | CN | disclosed |
| WO-2019037761-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 正大天晴药业集团股份有限公司 | 2019-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200291042-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | MUSK, TK1, TYMP | CHRNB4 1508/4885CHRNA3 859/4885PDCD1LG2 3966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.