Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPN1 | P15169 | 1/20 | 0.49 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 2/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750097 | 0.82 | CPN1 (0.71) | CPN1CPB2ALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL8786263 | 0.80 | CRHBP (0.49) | ALDH1A1AKR1C3AKR1C2AKR1C1PTGS1 | |
| Hydrochloric Acid SCHEMBL1410650 | 0.79 | CRHBP (0.48) | ALDH1A1AKR1C3AKR1C2AKR1C1PTGS1 | |
| SCHEMBL1653534 | 0.77 | AKR1C3 (0.52) | CPN1CPB2ALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL29687004 | 0.77 | KYNU (0.51) | CPN1CPB2AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1820061 | 0.77 | KYNU (0.51) | CPN1CPB2AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1801772 | 0.77 | AKR1C3 (0.52) | CPN1CPB2ALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL1666938 | 0.76 | AKR1C3 (0.47) | CPN1CPB2ALDH1A1AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL27319426 | 0.76 | LMNA (0.56) | ALDH1A1SMN1; SMN2MEN1POLBKMT2A | |
| SCHEMBL2109907 | 0.76 | MEN1 (0.63) | CPN1CPB2ALDH1A1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163756-B2 | For example,1-(3-t-butyl-1- (1,2,3,4-tetrahydro- isoquinolin-6-yl)-1H- pyrazol-5-yl)-3-(3- cyanophenyl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| US-20070078121-A1 | Enzyme modulators and treatments | DECIPHERA PHARMACEUTICALS, LLC | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078121-A1 | Enzyme modulators and treatments | ABL1, ABL2, LCK | CPN1 2320/4885CPB2 952/4885ALDH1A1 1036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.