Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11102725 | 0.93 | ALDH1A1 (0.56) | KEAP1ALDH1A1L3MBTL1AKR1B1NFE2L2 | |
| SCHEMBL19202478 | 0.89 | MAPT (0.48) | KEAP1ALDH1A1L3MBTL1AKR1B1NFE2L2 | |
| SCHEMBL11884130 | 0.87 | AKR1B1 (0.55) | ALDH1A1AKR1B1TDP1CYP1A2DUSP3 | |
| SCHEMBL2956925 | 0.86 | ALDH1A1 (0.56) | KEAP1ALDH1A1L3MBTL1AKR1B1TDP1 | |
| SCHEMBL5154125 | 0.83 | PTGER1 (0.54) | KEAP1ALDH1A1L3MBTL1NFE2L2CYP1A2 | |
| SCHEMBL22357534 | 0.83 | TDP1 (0.43) | KEAP1ALDH1A1L3MBTL1AKR1B1TDP1 | |
| SCHEMBL10686141 | 0.80 | ALDH1A1 (0.50) | KEAP1ALDH1A1L3MBTL1NFE2L2TDP1 | |
| SCHEMBL5347523 | 0.79 | KEAP1 (0.50) | KEAP1ALDH1A1L3MBTL1NFE2L2TDP1 | |
| SCHEMBL5150190 | 0.79 | ALDH1A1 (0.52) | KEAP1ALDH1A1L3MBTL1NFE2L2POLB | |
| SCHEMBL31256477 | 0.78 | ELANE (0.68) | ALDH1A1L3MBTL1AKR1B1TDP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163750-B2 | Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90 | SANOFI-AVENTIS (FR) | 2012-04-24 | — | — | US | disclosed |
| US-20100130503-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | SANOFI-AVENTIS (FR) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130503-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | HSP90AB2P, HSPA2, HSP90AB1 | KEAP1 602/4885ALDH1A1 2540/4885L3MBTL1 3321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.