SCHEMBL20798544

SCHEMBL20798544

O=c1c(O)c(-c2ccc(O)cc2)oc2ccc(O)c(O)c12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 10/20 0.68
KMT2A Q03164 10/20 0.68
CYP3A4 P08684 9/20 0.68
HSD17B10 Q99714 8/20 0.68
KDM4E B2RXH2 7/20 0.68
CYP2C9 P11712 7/20 0.68
MAPT P10636 7/20 0.68
HPGD P15428 6/20 0.68
TP53 P04637 6/20 0.68
ALOX15 P16050 6/20 0.68
ALDH1A1 P00352 5/20 0.68
FTO Q9C0B1 5/20 0.68
ABCB1 P08183 5/20 0.68
CYP2D6 P10635 4/20 0.68
CYP2C19 P33261 4/20 0.68
CYP1A2 P05177 4/20 0.68
LMNA P02545 4/20 0.68
BCHE P06276 4/20 0.68
ACHE P22303 4/20 0.68
XDH P47989 4/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28430943 0.87 TP53 (0.60) MEN1KMT2ACYP3A4HSD17B10KDM4E
SCHEMBL471861 0.87 MEN1 (0.71) MEN1KMT2ACYP3A4HSD17B10KDM4E
SCHEMBL4879748 0.85 AMY1A (0.78) MEN1KMT2ACYP3A4HSD17B10KDM4E
6-Hydroxykaempferol SCHEMBL674949 0.84 AMY1A (0.76) MEN1KMT2ACYP3A4HSD17B10KDM4E
6-Hydroxykaempferol SCHEMBL29725747 0.84 AMY1A (0.76) MEN1KMT2ACYP3A4HSD17B10KDM4E
SCHEMBL8749579 0.83 MAOA (0.70) MEN1KMT2ACYP3A4HSD17B10KDM4E
SCHEMBL29569956 0.83 MEN1 (0.71) MEN1KMT2ACYP3A4HSD17B10KDM4E
SCHEMBL10335363 0.82 MEN1 (0.79) MEN1KMT2ACYP3A4HSD17B10KDM4E
Kaempferol SCHEMBL1259228 0.81 MEN1 (1.00) MEN1KMT2ACYP3A4HSD17B10KDM4E
Kaempferol SCHEMBL29378805 0.81 MEN1 (1.00) MEN1KMT2ACYP3A4HSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11117987-B2 Hydroxyaryl functionalized polymers BRIDGESTONE CORPORATION (JP) 2021-09-14 US disclosed
US-11028195-B2 Hydroxyaryl functionalized polymers BRIDGESTONE CORPORATION (JP) 2021-06-08 US disclosed
US-20190322777-A1 Hydroxyaryl Functionalized Polymers BRIDGESTONE CORPORATION (JP) 2019-10-24 US disclosed
US-10370475-B2 Elastomeric compounds having increased cold flow resistance and methods producing the same BRIDGESTONE CORPORATION (JP) 2019-08-06 US disclosed
US-20190233557-A1 Hydroxyaryl Functionalized Polymers BRIDGESTONE CORPORATION (JP) 2019-08-01 US disclosed
US-10227425-B2 Hydroxyaryl functionalized polymers BRIDGESTONE CORPORATION (JP) 2019-03-12 US disclosed
CN-104478897-A Oxazino-scutellarin aglycone derivative as well as preparation method and application thereof UNIV NANJING CHINESE MEDICINE 2015-04-01 CN disclosed
CN-102702155-B Scutellarin aglycone methylate product based on in-vivo metabolic mechanism as well as preparation method and application of scutellarin aglycone methylate product UNIV NANJING CHINESE MEDICINE 2014-05-07 CN disclosed
CN-102702155-A Scutellarin aglycone methylate product based on in-vivo metabolic mechanism as well as preparation method and application of scutellarin aglycone methylate product UNIV NANJING CHINESE MEDICINE 2012-10-03 CN disclosed
CN-102690308-A Scutellarin-7-glycosyl derivatives, and preparation method and application thereof UNIV NANJING CHINESE MEDICINE 2012-09-26 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190322777-A1 Hydroxyaryl Functionalized Polymers HAAO, HCAR3, VCL MEN1 4721/4885KMT2A 1705/4885CYP3A4 25/4885
US-11028195-B2 Hydroxyaryl functionalized polymers HAAO, HCAR3, VCL MEN1 4769/4885KMT2A 1828/4885CYP3A4 30/4885
US-10227425-B2 Hydroxyaryl functionalized polymers HAAO, HCAR3, VCL MEN1 4721/4885KMT2A 1705/4885CYP3A4 25/4885
US-11117987-B2 Hydroxyaryl functionalized polymers HAAO, HCAR3, VCL MEN1 4721/4885KMT2A 1705/4885CYP3A4 25/4885
US-20190233557-A1 Hydroxyaryl Functionalized Polymers HAAO, HCAR3, VCL MEN1 4769/4885KMT2A 1828/4885CYP3A4 30/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.