Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 11/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.60 |
| ▸ | HTT | P42858 | 6/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242405 | 0.89 | ALDH1A1 (0.50) | LMNAALDH1A1HTTNPSR1HPGD | |
| SCHEMBL5929729 | 0.88 | ALDH1A1 (0.52) | LMNAALDH1A1HTTNPSR1HPGD | |
| SCHEMBL11792492 | 0.88 | ALDH1A1 (0.49) | LMNAALDH1A1HTTNPSR1HPGD | |
| SCHEMBL20799493 | 0.87 | ALDH1A1 (0.65) | LMNAALDH1A1HTTNPSR1HPGD | |
| SCHEMBL5929721 | 0.80 | LMNA (0.53) | LMNAALDH1A1HTTNPSR1HPGD | |
| SCHEMBL2605617 | 0.79 | DPP4 (0.49) | LMNAALDH1A1HTTNPSR1HPGD | |
| SCHEMBL25656349 | 0.79 | KMT2A (0.48) | LMNAALDH1A1NPSR1SMN1; SMN2MAPT | |
| SCHEMBL11791126 | 0.77 | ALDH1A1 (0.48) | LMNAALDH1A1HTTNPSR1HPGD | |
| SCHEMBL17384693 | 0.76 | LMNA (0.52) | LMNAALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL2605586 | 0.76 | ALDH1A1 (0.44) | LMNAALDH1A1HTTNPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227355-B2 | Quinoline derivatives and preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2019-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227355-B2 | Quinoline derivatives and preparation thereof | ABL1, FLT3, MAP3K7 | LMNA 2995/4885ALDH1A1 2096/4885HTT 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.