Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20801301 | 0.91 | KCNH2 (0.41) | SMN1; SMN2ALDH1A1L3MBTL1TP53HSP90AA1 | |
| SCHEMBL17694149 | 0.87 | EPHX1 (0.48) | SMN1; SMN2ALDH1A1L3MBTL1TP53HSP90AA1 | |
| SCHEMBL14541275 | 0.77 | TDP1 (0.50) | SMN1; SMN2ALDH1A1L3MBTL1TP53HSP90AA1 | |
| SCHEMBL19018969 | 0.75 | ALDH1A1 (0.78) | SMN1; SMN2ALDH1A1L3MBTL1TP53HSP90AA1 | |
| SCHEMBL25039583 | 0.74 | GRIA4 (0.41) | SMN1; SMN2ALDH1A1L3MBTL1TP53HSP90AA1 | |
| SCHEMBL21799960 | 0.74 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1L3MBTL1TP53HSP90AA1 | |
| SCHEMBL27398194 | 0.74 | CRHR1 (0.46) | SMN1; SMN2ALDH1A1L3MBTL1TP53HSP90AA1 | |
| SCHEMBL23625284 | 0.74 | NFKB1 (0.44) | SMN1; SMN2ALDH1A1L3MBTL1TSHRTDP1 | |
| SCHEMBL9336969 | 0.74 | KCNH2 (0.42) | SMN1; SMN2TDP1LMNAMEN1KMT2A | |
| SCHEMBL3130813 | 0.73 | NFKB1 (0.45) | SMN1; SMN2ALDH1A1L3MBTL1TP53HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3453710-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2019-03-13 | — | — | EP | disclosed |