Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20801300 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDL3MBTL1CRHBPCRHR2 | |
| SCHEMBL9336969 | 0.85 | KCNH2 (0.42) | KCNH2SMN1; SMN2CYP2D6TDP1DRD1 | |
| SCHEMBL17694149 | 0.79 | EPHX1 (0.48) | KCNH2SMN1; SMN2HPGDL3MBTL1CRHBP | |
| SCHEMBL9339052 | 0.72 | HTT (0.45) | SMN1; SMN2HPGDL3MBTL1NPC1RAB9A | |
| SCHEMBL25560558 | 0.72 | TLR8 (0.45) | KCNH2SMN1; SMN2L3MBTL1RAB9ACYP2D6 | |
| SCHEMBL10527323 | 0.72 | MAPT (0.46) | KCNH2SMN1; SMN2HPGDL3MBTL1NPC1 | |
| SCHEMBL25039432 | 0.70 | LMNA (0.39) | SMN1; SMN2NPC1RAB9AKIF11MEN1 | |
| SCHEMBL14541275 | 0.70 | TDP1 (0.50) | KCNH2SMN1; SMN2L3MBTL1ALDH1A1TP53 | |
| SCHEMBL22864455 | 0.69 | FPR2 (0.44) | SMN1; SMN2L3MBTL1RAB9AALDH1A1TP53 | |
| SCHEMBL31572051 | 0.69 | TAS1R3 (0.46) | SMN1; SMN2ALDH1A1TP53TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3453710-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2019-03-13 | — | — | EP | disclosed |