SCHEMBL2080415

SCHEMBL2080415

CON1CCC(Br)C1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7632237 0.77
SCHEMBL2081232 0.77 CASP3 (0.31)
SCHEMBL2077624 0.76
SCHEMBL14301508 0.76
SCHEMBL10371339 0.75 ROCK2 (0.32)
SCHEMBL20041885 0.72 NAAA (0.33)
SCHEMBL991944 0.71
SCHEMBL20931143 0.71
SCHEMBL19559425 0.71 NAAA (0.33)
SCHEMBL19559454 0.70 CYP1A2 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-63119461-A None JP disclosed
EP-2024330-B1 PRODUCTION METHOD OF HETEROCYCLIC MERCAPTO COMPOUND SHOWA DENKO KK (JP) 2012-04-25 EP disclosed
US-7902383-B2 Production method of heterocyclic mercapto compound SHOWA DENKO K.K. (JP) 2011-03-08 US disclosed
US-20090171095-A1 PRODUCTION METHOD OF HETEROCYCLIC MERCAPTO COMPOUND SHOWA DENKO K.K. (JP) 2009-07-02 US disclosed
EP-2024330-A1 PRODUCTION METHOD OF HETEROCYCLIC MERCAPTO COMPOUND Showa Denko K.K. (JP) 2009-02-18 EP disclosed
WO-2007139215-A1 PRODUCTION METHOD OF HETEROCYCLIC MERCAPTO COMPOUND SHOWA DENKO K.K. (JP) 2007-12-06 WO disclosed
EP-0888323-A1 DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS THE PROCTER & GAMBLE COMPANY (US) 1999-01-07 EP disclosed
WO-1997028147-A1 DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS THE PROCTER & GAMBLE COMPANY (US) 1997-08-07 WO disclosed
US-5618835-A ANALGESICS THE PROCTER & GAMBLE COMPANY (US) 1997-04-08 US disclosed
US-5348957-A Gastrointestinal ulcer treatment WARNER-LAMBERT COMPANY (US) 1994-09-20 US disclosed
US-5270319-A 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents WARNER-LAMBERT COMPANY (US) 1993-12-14 US disclosed
WO-1993005039-A1 5-HYDROXY-2-PYRIMIDINYLMETHYLENE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS WARNER-LAMBERT COMPANY (US) 1993-03-18 WO disclosed
EP-0204964-B1 2-PYRROLIDONE DERIVATIVES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE Eisai Co., Ltd. (JP) 1991-08-28 EP disclosed
US-4833160-A ANTIINFLAMMATORY AGENTS, ANALGESICS EISAI CO., LTD. (JP) 1989-05-23 US disclosed
JP-S63119461-A 2-PYRROLIDONE DERIVATIVE EISAI CO LTD 1988-05-24 JP disclosed
EP-0204964-A1 2-Pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use Eisai Co., Ltd. (JP) 1986-12-17 EP disclosed