Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18966760 | 0.81 | PARP1 (0.34) | PARP1 | |
| SCHEMBL22474799 | 0.80 | ALDH1A1 (0.35) | PARP1MAPTNPC1ALDH1A1ALOX15 | |
| SCHEMBL23644550 | 0.78 | PARP1 (0.42) | PARP1CASP6ALDH1A1ALOX15 | |
| SCHEMBL23837552 | 0.76 | MTNR1A (0.36) | MAPTNPC1RAB9AALOX15 | |
| SCHEMBL22474786 | 0.76 | HPGD (0.40) | KDM4ERAB9AALDH1A1HPGDHSD17B10 | |
| SCHEMBL23130227 | 0.72 | KMT2A (0.44) | LMNA | |
| SCHEMBL23837606 | 0.71 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL4829723 | 0.70 | PARP1 (0.74) | PARP1 | |
| SCHEMBL20807132 | 0.69 | PARP1 (0.36) | PARP1KDM4EAPAF1RECQLCASP6 | |
| SCHEMBL23129889 | 0.68 | ALDH1A1 (0.43) | LMNAMAPTKDM4EALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943204-B1 | BETA-LACTAMASE INHIBITORS | VENATORX PHARMACEUTICALS INC (US) | 2019-03-13 | — | — | EP | disclosed |