Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 3/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20786908 | 0.87 | ITGB3 (0.51) | PSMB1PSMB5ITGB3ITGA2BKDM4E | |
| SCHEMBL20808748 | 0.82 | LMNA (0.46) | ITGB3ITGA2BKDM4EKMT2ANLRP3 | |
| SCHEMBL24248436 | 0.82 | ITGB3 (0.45) | PSMB1PSMB5ITGB3ITGA2BKDM4E | |
| SCHEMBL20786929 | 0.82 | PSMB1 (0.57) | PSMB1PSMB5KDM4EPOLBKMT2A | |
| SCHEMBL20786915 | 0.82 | PSMB1 (0.48) | PSMB1PSMB5ITGB3ITGA2BKDM4E | |
| SCHEMBL2008953 | 0.80 | HTR2A (0.55) | KMT2AHTR2AHTR2CNTSR1LMNA | |
| SCHEMBL20786909 | 0.80 | KDM4E (0.50) | PSMB1PSMB5KDM4EKMT2AALDH1A1 | |
| SCHEMBL20786895 | 0.80 | PSMB1 (0.61) | PSMB1PSMB5KDM4EPOLBKMT2A | |
| SCHEMBL20786879 | 0.80 | TNF (0.51) | PSMB1PSMB5KDM4EPOLBKMT2A | |
| SCHEMBL21025554 | 0.79 | ITGB3 (0.42) | PSMB1PSMB5ITGB3ITGA2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3453707-B1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2022-02-16 | — | — | EP | disclosed |
| EP-3453707-A1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai de Novo Pharmatech Co., Ltd. (CN) | 2019-03-13 | — | — | EP | disclosed |