Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27109564 | 0.81 | KDM4E (0.42) | KDM4ENPC1GAAMAPTTHRB | |
| SCHEMBL24067423 | 0.78 | KDM4E (0.40) | KDM4ENPC1GAAMAPTTHRB | |
| SCHEMBL20813844 | 0.77 | HTR1A (0.49) | PDE5AEGFRMEN1KMT2AHPGD | |
| SCHEMBL20813842 | 0.70 | CYP1A2 (0.42) | KDM4EMAPTPDE5APDE1BALDH1A1 | |
| SCHEMBL20814021 | 0.70 | NOTUM (0.36) | PDE1BPDE1APDE1C | |
| SCHEMBL20813448 | 0.69 | PDE5A (0.41) | KDM4EGAAMAPTMAPK1PDE5A | |
| SCHEMBL20813790 | 0.67 | SLC6A3 (0.39) | MAPTCLK1EGFRMEN1KMT2A | |
| SCHEMBL17142275 | 0.67 | PDE5A (0.51) | KDM4ENPC1MAPTPDE5APDE1B | |
| SCHEMBL1710455 | 0.66 | ALDH1A1 (0.50) | KDM4ENPC1GAAMAPTTHRB | |
| SCHEMBL1014275 | 0.66 | ALDH1A1 (0.50) | KDM4ENPC1GAAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327882-A2 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER | The Board of Trustees of the Leland Stanford Junior University (US) | 2024-02-28 | — | — | EP | disclosed |
| WO-2023077083-A1 | ENPP1 INHIBITORS AS INHIBITORS OF METASTASIS | ANGARUS THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2021226136-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | ANGARUS THERAPEUTICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |
| WO-2019051269-A1 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-03-14 | — | — | WO | disclosed |