Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20813475 | 0.81 | KDM4E (0.41) | KDM4ENPC1GAAMAPTTHRB | |
| SCHEMBL12844112 | 0.81 | PDE1B (0.55) | KDM4EMAPTPDE5APDE1BPDE1A | |
| SCHEMBL24067423 | 0.79 | KDM4E (0.40) | KDM4ENPC1GAAMAPTTHRB | |
| SCHEMBL11583026 | 0.77 | HTR1A (0.50) | KDM4EALDH1A1EGFR | |
| SCHEMBL24393048 | 0.76 | PDE1B (0.38) | PDE5APDE1BPDE1APDE1CALDH1A1 | |
| SCHEMBL27109596 | 0.72 | PDE1B (0.33) | PDE5APDE1BPDE1APDE1C | |
| SCHEMBL20813807 | 0.68 | PDE5A (0.42) | KDM4EGAAPDE5ACYP3A4EGFR | |
| SCHEMBL11208368 | 0.68 | MAPT (0.67) | KDM4ENPC1GAAMAPTTHRB | |
| SCHEMBL17142275 | 0.68 | PDE5A (0.51) | KDM4ENPC1MAPTPDE5APDE1B | |
| SCHEMBL1014275 | 0.67 | ALDH1A1 (0.50) | KDM4ENPC1GAAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327882-A2 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER | The Board of Trustees of the Leland Stanford Junior University (US) | 2024-02-28 | — | — | EP | disclosed |