Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20816620 | 1.00 | MMP9 (0.50) | MMP9MMP8PTPN1MMP14OPRD1 | |
| SCHEMBL20827855 | 0.89 | PTPN1 (0.60) | MMP9MMP8PTPN1MMP14CTSB | |
| SCHEMBL20816763 | 0.89 | MMP9 (0.47) | MMP9MMP8PTPN1MMP14OPRD1 | |
| SCHEMBL20816841 | 0.89 | MMP9 (0.47) | MMP9MMP8PTPN1MMP14OPRD1 | |
| SCHEMBL20816548 | 0.87 | FCER2 (0.56) | MMP9MMP8PTPN1OPRD1MME | |
| SCHEMBL20816656 | 0.87 | FCER2 (0.56) | MMP9MMP8PTPN1OPRD1MME | |
| SCHEMBL20816664 | 0.86 | PTPN1 (0.58) | PTPN1MMEACECPA1ACE2 | |
| SCHEMBL20816662 | 0.86 | PTPN1 (0.58) | PTPN1MMEACECPA1ACE2 | |
| SCHEMBL20816899 | 0.86 | PTPN1 (0.58) | PTPN1MMEACECPA1ACE2 | |
| SCHEMBL20816879 | 0.86 | PTPN1 (0.58) | PTPN1MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | Phelix Therapeutics (US) | 2019-03-21 | — | — | US | disclosed |
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | Phelix Therapeutics (US) | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | CTSS, CTSB, CTSL | MMP9 618/4885MMP8 238/4885PTPN1 4631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.