Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30525062 | 1.00 | LOXL2 (0.41) | LOXL2TRPA1ALDH1A1NAMPTUSP2 | |
| SCHEMBL20791163 | 1.00 | LOXL2 (0.41) | LOXL2TRPA1ALDH1A1NAMPTUSP2 | |
| SCHEMBL20791162 | 1.00 | LOXL2 (0.41) | LOXL2TRPA1ALDH1A1NAMPTUSP2 | |
| SCHEMBL20817825 | 1.00 | LOXL2 (0.41) | LOXL2TRPA1ALDH1A1NAMPTUSP2 | |
| SCHEMBL20790685 | 0.98 | TRPA1 (0.41) | LOXL2TRPA1NAMPT | |
| SCHEMBL20811435 | 0.98 | TRPA1 (0.41) | LOXL2TRPA1NAMPT | |
| SCHEMBL22245612 | 0.98 | TRPA1 (0.41) | LOXL2TRPA1NAMPT | |
| SCHEMBL20790648 | 0.98 | TRPA1 (0.41) | LOXL2TRPA1NAMPT | |
| SCHEMBL26398092 | 0.90 | USP2 (0.43) | ALDH1A1USP2 | |
| SCHEMBL20791137 | 0.90 | LOXL2 (0.44) | LOXL2TRPA1ALDH1A1NAMPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111601798-B | Bisamide sarcomere activating compounds and uses thereof | 美国安进公司 | 2023-08-11 | — | — | CN | claimed |
| CN-111601798-B | Bisamide sarcomere activating compounds and uses thereof | 美国安进公司 | 2023-08-11 | — | — | CN | disclosed |
| US-11299479-B1 | Bisamide sarcomere activating compounds and uses thereof | CYTOKINETICS, INC. (US) | 2022-04-12 | — | — | US | disclosed |
| US-10899746-B2 | Bisamide sarcomere activating compounds and uses thereof | AMGEN INC. (US) | 2021-01-26 | — | — | US | disclosed |
| CN-111601798-A | Bisamide sarcomere activating compound and use thereof | 美国安进公司 | 2020-08-28 | — | — | CN | disclosed |
| EP-3681882-A1 | BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF | Amgen Inc. (US) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019055590-A1 | BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF | AMGEN INC. (US) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11299479-B1 | Bisamide sarcomere activating compounds and uses thereof | TNNI3, TNNT2, TNNC1 | LOXL2 3954/4885TRPA1 384/4885ALDH1A1 3628/4885 |
| US-10899746-B2 | Bisamide sarcomere activating compounds and uses thereof | TNNI3, TNNT2, TNNC1 | LOXL2 3954/4885TRPA1 384/4885ALDH1A1 3628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.