Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979237 | 0.89 | GABRA1 (0.49) | GABRA1GABRB2GABRA5GABRA3GABRA2 | |
| SCHEMBL4985136 | 0.86 | GABRA1 (0.47) | GABRA1GABRB2GABRA5GABRA3GABRA2 | |
| SCHEMBL20819295 | 0.85 | RORC (0.59) | GABRA1GABRB2GABRA5GABRA3GABRA2 | |
| SCHEMBL5952426 | 0.83 | ALDH1A1 (0.59) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL14188849 | 0.83 | GABRA1 (0.45) | GABRA1GABRB2GABRA5GABRA3GABRA2 | |
| SCHEMBL8415025 | 0.82 | KDM4E (0.46) | GABRA1GABRB2GABRA5GABRA3GABRA2 | |
| SCHEMBL20819329 | 0.81 | KDM4E (0.55) | GABRA1GABRB2GABRA5GABRA3GABRA2 | |
| SCHEMBL4986308 | 0.81 | RAB9A (0.48) | GABRA1GABRB2GABRA5GABRA3GABRA2 | |
| SCHEMBL4981784 | 0.81 | ALDH1A1 (0.61) | ALDH1A1ALOX5POLBHPGDPTGS1 | |
| SCHEMBL8205051 | 0.81 | GABRA1 (0.53) | GABRA1GABRB2GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019053617-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-21 | — | — | WO | disclosed |