Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20303428 | 0.73 | TSHR (0.35) | TSHRALDH1A1 | |
| SCHEMBL20168189 | 0.73 | TSHR (0.45) | TSHR | |
| SCHEMBL10073213 | 0.69 | GPR84 (0.32) | — | |
| SCHEMBL296498 | 0.69 | TSHR (0.45) | TSHR | |
| SCHEMBL102473 | 0.65 | CYP1A2 (0.59) | TSHRKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL3395408 | 0.65 | — | — | |
| SCHEMBL20822276 | 0.65 | SOS1 (0.31) | — | |
| SCHEMBL8851985 | 0.65 | KDM4E (0.46) | TSHRKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL473873 | 0.65 | KDM4E (0.37) | TSHRKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL1344362 | 0.65 | KDM4E (0.46) | KDM4EALDH1A1MAPTHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200148693-A1 | Chemical Compounds | AVISTA PHARMA SOLUTIONS INC (US) | 2020-05-14 | — | — | US | disclosed |
| US-10570144-B2 | Substituted ureas as prostaglandin EP4 receptor antagonists | AVISTA PHARMA SOLUTIONS, INC. (US) | 2020-02-25 | — | — | US | disclosed |
| US-10239885-B1 | Compound 1-[2-[4-(2-ethyl-6,8-dimethylimidazo[1,2-α]pyrazin-3-yl)phenyl]ethyl]-3-(p-tolylsulfonyl)urea as a prostaglandin EP4 receptor antagonist | AVISTA PHARMA SOLUTIONS, INC. (US) | 2019-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148693-A1 | Chemical Compounds | PTGER4, PTGES, PTGER1 | TSHR 1808/4885KDM4E 1581/4885ALDH1A1 1128/4885 |
| US-10239885-B1 | Compound 1-[2-[4-(2-ethyl-6,8-dimethylimidazo[1,2-α]pyrazin-3-yl)phenyl]ethyl]-3-(p-tolylsulfonyl)urea as a prostaglandin EP4 receptor antagonist | PTGER4, PTGER1, PTGER2 | TSHR 421/4885KDM4E 331/4885ALDH1A1 887/4885 |
| US-10570144-B2 | Substituted ureas as prostaglandin EP4 receptor antagonists | PTGER4, PTGER1, PTGER2 | TSHR 1071/4885KDM4E 1551/4885ALDH1A1 858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.