Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2083187 | 1.00 | APAF1 (0.43) | APAF1CYP3A4CYP2C19KCNA3OPRM1 | |
| SCHEMBL24629686 | 0.86 | POLB (0.43) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL25831273 | 0.78 | APAF1 (0.53) | APAF1CYP3A4CYP2C19OPRM1SMN1; SMN2 | |
| SCHEMBL25297216 | 0.78 | APAF1 (0.53) | APAF1CYP3A4CYP2C19OPRM1SMN1; SMN2 | |
| SCHEMBL13483586 | 0.77 | MME (0.50) | CYP3A4CYP2C19SMN1; SMN2TSHRMEN1 | |
| SCHEMBL13659728 | 0.74 | GAA (0.46) | CYP3A4CYP2C19KCNA3OPRM1SMN1; SMN2 | |
| SCHEMBL3258696 | 0.74 | SMN1; SMN2 (0.49) | CYP3A4CYP2C19KCNA3OPRM1SMN1; SMN2 | |
| SCHEMBL3258693 | 0.74 | SMN1; SMN2 (0.49) | CYP3A4CYP2C19KCNA3OPRM1SMN1; SMN2 | |
| SCHEMBL16847413 | 0.73 | HPGD (0.45) | CYP3A4CYP2C19SMN1; SMN2GAAMEN1 | |
| SCHEMBL7956888 | 0.72 | APAF1 (0.39) | APAF1CYP3A4CYP2C19KCNA3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902226-B2 | Dehalogeno-compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-03-08 | — | — | US | disclosed |
| EP-1336611-B1 | DEHALOGENO COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2007-09-05 | — | — | EP | disclosed |
| US-20070123560-A1 | Dehalogeno-compounds | DAIICHI PHARMACEUTICAL CO., LTD. | 2007-05-31 | — | — | US | disclosed |
| US-20040063754-A1 | Dehalogeno compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-01 | — | — | US | disclosed |
| EP-1336611-A1 | DEHALOGENO COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-08-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063754-A1 | Dehalogeno compounds | DEK, PGLS, RPS27L | APAF1 2770/4885CYP3A4 198/4885CYP2C19 45/4885 |
| US-20070123560-A1 | Dehalogeno-compounds | DEK, RPS27L, POLL | APAF1 2269/4885CYP3A4 277/4885CYP2C19 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.