Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258693 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2CYP3A4CYP2C19LMNAHPGD | |
| SCHEMBL13483586 | 0.82 | MME (0.50) | SMN1; SMN2CYP3A4CYP2C19LMNAHPGD | |
| SCHEMBL3259891 | 0.81 | LMNA (0.51) | LMNAHPGDALDH1A1RECQLMEN1 | |
| SCHEMBL3259889 | 0.81 | LMNA (0.51) | LMNAHPGDALDH1A1RECQLMEN1 | |
| SCHEMBL14960649 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2CYP3A4CYP2C19LMNAOPRM1 | |
| SCHEMBL11155829 | 0.76 | CYP3A4 (0.42) | SMN1; SMN2CYP3A4CYP2C19KCNA3OPRM1 | |
| SCHEMBL15461468 | 0.76 | ALDH1A1 (0.37) | SMN1; SMN2CYP3A4CYP2C19LMNAOPRM1 | |
| SCHEMBL15461485 | 0.75 | ALDH1A1 (0.36) | SMN1; SMN2CYP3A4CYP2C19OPRM1ALDH1A1 | |
| SCHEMBL15461439 | 0.74 | ALDH1A1 (0.38) | SMN1; SMN2CYP3A4CYP2C19LMNAOPRM1 | |
| SCHEMBL2083186 | 0.74 | APAF1 (0.43) | SMN1; SMN2CYP3A4CYP2C19KCNA3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41149-E1 | Stereoisomerically pure 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluoro-1-cyclopropyl]-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid or a pharmaceutically acceptable salt thereof; antibacterial agents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-6031102-A | Optically active pyridonecarboxylic acid derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| US-5587386-A | BACTERICIDES, MICROBIOCIDES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |