Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.57 |
| ▸ | CTSD | P07339 | 2/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21012316 | 0.90 | REN (0.60) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21457987 | 0.88 | CTSS (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3842768 | 0.88 | CTSS (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21457973 | 0.88 | CTSS (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7305781 | 0.88 | REN (0.69) | REN | |
| SCHEMBL28525268 | 0.87 | REN (0.59) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28525265 | 0.87 | REN (0.59) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28525267 | 0.87 | REN (0.59) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3859084 | 0.86 | PSMB1 (0.52) | RENCTSDBACE1PSMB1 | |
| SCHEMBL20474450 | 0.86 | PSMB1 (0.52) | RENCTSDBACE1PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190270770-A1 | DIPEPTIDYL KETOAMIDE COMPOUNDS AND THEIR USE FOR THE TREATMENT AND/OR PREVENTION OF FAT ACCUMULATION | LANDSTEINER GENMED S L | 2019-09-05 | — | — | US | disclosed |
| US-10294269-B2 | Dipeptidyl ketoamide compounds and their use for the treatment and/or prevention of fat accumulation | LANDSTEINER GENMED, S.L. (ES) | 2019-05-21 | — | — | US | disclosed |
| EP-3191112-B1 | DIPEPTIDYL KETOAMIDE COMPOUNDS AND THEIR USE FOR THE TREATMENT AND/OR PREVENTION OF FAT ACCUMULATION | LANDSTEINER GENMED S L (ES) | 2019-03-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10294269-B2 | Dipeptidyl ketoamide compounds and their use for the treatment and/or prevention of fat accumulation | DPP4, DPP3, DPP8 | REN 417/4885PSEN1 1439/4885PSEN2 1900/4885 |
| US-20190270770-A1 | DIPEPTIDYL KETOAMIDE COMPOUNDS AND THEIR USE FOR THE TREATMENT AND/OR PREVENTION OF FAT ACCUMULATION | DPP4, DPP3, DPP8 | REN 417/4885PSEN1 1439/4885PSEN2 1900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.