Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19631388 | 1.00 | DHODH (1.00) | DHODH | |
| SCHEMBL29621431 | 1.00 | DHODH (1.00) | DHODH | |
| SCHEMBL19631436 | 0.92 | DHODH (0.85) | DHODH | |
| SCHEMBL28664519 | 0.91 | DHODH (0.83) | DHODH | |
| SCHEMBL19631450 | 0.91 | DHODH (0.83) | DHODH | |
| SCHEMBL28664518 | 0.91 | DHODH (0.83) | DHODH | |
| SCHEMBL29859318 | 0.90 | DHODH (1.00) | DHODH | |
| SCHEMBL20836122 | 0.90 | DHODH (1.00) | DHODH | |
| SCHEMBL19631349 | 0.90 | DHODH (1.00) | DHODH | |
| SCHEMBL28975796 | 0.90 | DHODH (0.81) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117769544-A | Polysubstituted thiazole derivative and application thereof in disease treatment | 上海汇伦医药股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113773275-B | Antiviral compound and preparation method thereof | 广东中科药物研究有限公司 | 2023-04-25 | — | — | CN | disclosed |
| US-11590109-B2 | Applications of novel thiazole derivative in treating virus infection | INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES (CN) | 2023-02-28 | — | — | US | disclosed |
| CN-115701427-A | Polysubstituted thiazole derivatives and their use in the treatment of diseases | 上海汇伦医药股份有限公司 | 2023-02-10 | — | — | CN | disclosed |
| WO-2023011312-A1 | MULTI-SUBSTITUTED THIAZOLE DERIVATIVE AND APPLICATION THEREOF IN DISEASE TREATMENT | 上海汇伦医药股份有限公司 | 2023-02-09 | — | — | WO | disclosed |
| US-11534427-B2 | Applications of novel thiazole derivative in treating inflammatory bowel diseases | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2022-12-27 | — | — | US | disclosed |
| CN-107375279-B | Use of novel thiazole derivatives for the treatment of inflammatory bowel disease | 华东理工大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-107382902-B | Thiazole derivative and application thereof | 华东理工大学 | 2022-08-12 | — | — | CN | disclosed |
| CN-107459496-B | Use of thiazole derivatives for treating viral infections | 华东理工大学 | 2022-07-19 | — | — | CN | disclosed |
| CN-113416172-B | Antiviral compound and preparation method thereof | 广东中科药物研究有限公司 | 2022-06-21 | — | — | CN | disclosed |
| EP-3459937-B1 | THIAZOLE DERIVATIVE AND APPLICATIONS | UNIV EAST CHINA SCIENCE & TECH (CN) | 2021-12-29 | — | — | EP | disclosed |
| CN-113773275-A | Antiviral compound and preparation method thereof | 广东中科药物研究有限公司 | 2021-12-10 | — | — | CN | disclosed |
| CN-113416172-A | Antiviral compound and preparation method thereof | 广东中科药物研究有限公司 | 2021-09-21 | — | — | CN | disclosed |
| CN-112707874-A | Antiviral compound and preparation method thereof | 广东中科药物研究有限公司 | 2021-04-27 | — | — | CN | disclosed |
| US-10919869-B2 | Thiazole derivative and applications | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-02-16 | — | — | US | disclosed |
| CN-106892878-B | Thiazole derivative and application thereof in inhibiting dihydroorotate dehydrogenase | 华东理工大学 | 2020-01-10 | — | — | CN | disclosed |
| US-20190292162-A1 | THIAZOLE DERIVATIVE AND APPLICATIONS | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2019-09-26 | — | — | US | disclosed |
| US-20190290620-A1 | APPLICATIONS OF NOVEL THIAZOLE DERIVATIVE IN TREATING INFLAMMATORY BOWEL DISEASES | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2019-09-26 | — | — | US | disclosed |
| US-20190134008-A1 | APPLICATIONS OF NOVEL THIAZOLE DERIVATIVE IN TREATING VIRUS INFECTION | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2019-05-09 | — | — | US | disclosed |
| EP-3459937-A1 | THIAZOLE DERIVATIVE AND APPLICATIONS | East China University of Science and Technology (CN) | 2019-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11534427-B2 | Applications of novel thiazole derivative in treating inflammatory bowel diseases | FABP2, SLC10A2, ALPI | DHODH 803/4885 |
| US-20190292162-A1 | THIAZOLE DERIVATIVE AND APPLICATIONS | DHODH, DLD, THOC2 | DHODH 1/4885 |
| US-20190290620-A1 | APPLICATIONS OF NOVEL THIAZOLE DERIVATIVE IN TREATING INFLAMMATORY BOWEL DISEASES | FABP2, SLC10A2, ALPI | DHODH 803/4885 |
| US-11590109-B2 | Applications of novel thiazole derivative in treating virus infection | HAVCR2, MAVS, EIF2AK2 | DHODH 1507/4885 |
| US-20190134008-A1 | APPLICATIONS OF NOVEL THIAZOLE DERIVATIVE IN TREATING VIRUS INFECTION | HAVCR2, MAVS, EIF2AK2 | DHODH 1507/4885 |
| US-10919869-B2 | Thiazole derivative and applications | DHODH, DLD, THOC2 | DHODH 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.