Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 17/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29859288 | 1.00 | DHODH (1.00) | DHODHMEN1KMT2AMAPK1RARA | |
| SCHEMBL19631362 | 1.00 | DHODH (1.00) | DHODHMEN1KMT2AMAPK1RARA | |
| SCHEMBL19631370 | 0.89 | DHODH (1.00) | DHODHMEN1KMT2AMAPK1RARA | |
| SCHEMBL20956542 | 0.89 | DHODH (1.00) | DHODHMEN1KMT2AMAPK1RARA | |
| SCHEMBL25613714 | 0.89 | DHODH (0.80) | DHODHMEN1KMT2AMAPK1 | |
| SCHEMBL29859659 | 0.89 | DHODH (1.00) | DHODHMEN1KMT2AMAPK1RARA | |
| SCHEMBL19631470 | 0.86 | DHODH (1.00) | DHODH | |
| SCHEMBL25613978 | 0.84 | DHODH (0.73) | DHODHMEN1KMT2AMAPK1LMNA | |
| SCHEMBL25614126 | 0.83 | DHODH (0.71) | DHODHMEN1KMT2AMAPK1RARA | |
| SCHEMBL24142109 | 0.78 | DHODH (0.64) | DHODHMEN1KMT2AMAPK1RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11590109-B2 | Applications of novel thiazole derivative in treating virus infection | INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES (CN) | 2023-02-28 | — | — | US | disclosed |
| CN-107375279-B | Use of novel thiazole derivatives for the treatment of inflammatory bowel disease | 华东理工大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-107382902-B | Thiazole derivative and application thereof | 华东理工大学 | 2022-08-12 | — | — | CN | disclosed |
| CN-107459496-B | Use of thiazole derivatives for treating viral infections | 华东理工大学 | 2022-07-19 | — | — | CN | disclosed |
| EP-3459937-B1 | THIAZOLE DERIVATIVE AND APPLICATIONS | UNIV EAST CHINA SCIENCE & TECH (CN) | 2021-12-29 | — | — | EP | disclosed |
| US-10919869-B2 | Thiazole derivative and applications | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-02-16 | — | — | US | disclosed |
| CN-106892878-B | Thiazole derivative and application thereof in inhibiting dihydroorotate dehydrogenase | 华东理工大学 | 2020-01-10 | — | — | CN | disclosed |
| US-20190134008-A1 | APPLICATIONS OF NOVEL THIAZOLE DERIVATIVE IN TREATING VIRUS INFECTION | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2019-05-09 | — | — | US | disclosed |
| EP-3459937-A1 | THIAZOLE DERIVATIVE AND APPLICATIONS | East China University of Science and Technology (CN) | 2019-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11590109-B2 | Applications of novel thiazole derivative in treating virus infection | HAVCR2, MAVS, EIF2AK2 | DHODH 1507/4885MEN1 4251/4885KMT2A 4585/4885 |
| US-20190134008-A1 | APPLICATIONS OF NOVEL THIAZOLE DERIVATIVE IN TREATING VIRUS INFECTION | HAVCR2, MAVS, EIF2AK2 | DHODH 1507/4885MEN1 4251/4885KMT2A 4585/4885 |
| US-10919869-B2 | Thiazole derivative and applications | DHODH, DLD, THOC2 | DHODH 1/4885MEN1 3352/4885KMT2A 4625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.