Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 2/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20837047 | 0.89 | MAT2A (0.33) | MAT2AMEN1HPGDHTTKMT2A | |
| SCHEMBL20914269 | 0.88 | MAT2A (0.33) | KDM4EALDH1A1LMNAMAPK1MAT2A | |
| SCHEMBL20931270 | 0.86 | POLB (0.33) | KDM4EALDH1A1MAT2APLATPOLB | |
| SCHEMBL20914019 | 0.85 | PLAT (0.32) | KDM4EALDH1A1LMNAMAPK1MAT2A | |
| SCHEMBL20914031 | 0.84 | APLNR (0.35) | KDM4EALDH1A1LMNAMAPK1MAT2A | |
| SCHEMBL20913983 | 0.80 | MAT2A (0.31) | MAT2APLAT | |
| SCHEMBL20914264 | 0.79 | F2RL3 (0.33) | KDM4EALDH1A1LMNAMAPK1MEN1 | |
| SCHEMBL20914298 | 0.78 | APLNR (0.39) | KDM4EALDH1A1MAT2AMEN1HPGD | |
| SCHEMBL20914059 | 0.77 | MAT2A (0.33) | KDM4EALDH1A1LMNAMAPK1MAT2A | |
| SCHEMBL20914308 | 0.76 | MAT2A (0.34) | KDM4EMAT2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738056-B2 | Pyrazolopyrimidinone compounds and uses thereof | ADURO BIOTECH INC. (US) | 2020-08-11 | — | — | US | disclosed |
| US-20190119285-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF | CHINOOK THERAPEUTICS, INC. | 2019-04-25 | — | — | US | disclosed |
| WO-2019055750-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF | Aduro Biotech, Inc. (US) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738056-B2 | Pyrazolopyrimidinone compounds and uses thereof | NLRP3, NLRP1, P2RX7 | KDM4E 1922/4885ALDH1A1 1246/4885LMNA 4242/4885 |
| US-20190119285-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF | NLRP3, NLRP1, P2RX7 | KDM4E 1922/4885ALDH1A1 1246/4885LMNA 4242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.