Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 2/20 | 0.47 |
| ▸ | F3 | P13726 | 2/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.45 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.42 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | MAP2 | P11137 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570293 | 0.89 | PRKAG1 (0.55) | F7F3MAP2K4ROCK1PRKAG1 | |
| SCHEMBL11220634 | 0.81 | KDM4E (0.54) | MAP2K4PRKAG1PRKAA1PRKAB1HAO1 | |
| SCHEMBL11015155 | 0.81 | JAK2 (0.51) | ROCK1PRKAG1PRKAA1PRKAB1HAO1 | |
| SCHEMBL4932564 | 0.81 | PRKAG1 (0.45) | MAP2K4PRKAG1PRKAA1PRKAB1HAO1 | |
| SCHEMBL27814101 | 0.80 | ROCK1 (0.49) | F7F3MAP2K4ROCK1PRKAG1 | |
| SCHEMBL11011467 | 0.80 | MAP2K4 (0.52) | MAP2K4PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL7379535 | 0.79 | MAP2K4 (0.61) | MAP2K4PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL30443279 | 0.79 | MAP2K4 (0.61) | MAP2K4PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL17324736 | 0.78 | ROCK1 (0.47) | F7F3MAP2K4ROCK1PRKAG1 | |
| SCHEMBL16246796 | 0.78 | JAK2 (0.48) | F7F3MAP2K4ROCK1FADS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111344293-A | 1, 3-dihydroimidazo [4, 5-c ] cinnolin-2-one compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2020-06-26 | — | — | CN | disclosed |
| WO-2019057757-A1 | 1,3-DIHYDROIMIDAZO[4,5-C]CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-03-28 | — | — | WO | disclosed |