Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MAP2 | P11137 | 3/20 | 0.47 |
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | FADS1 | O60427 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15540985 | 0.87 | MAP2K4 (0.52) | JAK2JAK1MAP2RBP4KDM4E | |
| SCHEMBL27814101 | 0.86 | ROCK1 (0.49) | JAK2JAK1ROCK1RBP4DYRK1A | |
| SCHEMBL570293 | 0.85 | PRKAG1 (0.55) | ROCK1F7F3MAP2K4 | |
| SCHEMBL17324736 | 0.83 | ROCK1 (0.47) | JAK2JAK1ROCK1MAP2RBP4 | |
| SCHEMBL23368472 | 0.83 | GSK3B (0.47) | JAK2JAK1DYRK1ANTRK1WNT1 | |
| SCHEMBL22518544 | 0.83 | ROCK1 (0.53) | JAK2JAK1ROCK1AURKAAURKB | |
| SCHEMBL8877161 | 0.81 | JAK2 (0.54) | JAK2JAK1DYRK1ANTRK1WNT1 | |
| SCHEMBL15942818 | 0.80 | MAP2K4 (0.62) | JAK2JAK1DYRK1ANTRK1WNT1 | |
| SCHEMBL17039120 | 0.80 | JAK2 (0.64) | JAK2JAK1AURKAAURKBDYRK1A | |
| SCHEMBL6195016 | 0.80 | DYRK1A (0.44) | JAK2JAK1DYRK1ANTRK1WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305778-A1 | INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2018-04-11 | — | — | EP | claimed |
| EP-3027605-B1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2017-11-08 | — | — | EP | claimed |
| US-9737510-B2 | Indazole compounds and a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-08-22 | — | — | US | claimed |
| CN-106103427-A | New indazole compound and preparation method thereof | 科学与工业研究会 | 2016-11-09 | — | — | CN | claimed |
| US-20160185759-A1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-06-30 | — | — | US | claimed |
| EP-3027605-A1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2016-06-08 | — | — | EP | claimed |
| EP-2999697-A1 | HETEROCYCLIC DERIVATES | Kalvista Pharmaceuticals Limited (GB) | 2016-03-30 | — | — | EP | claimed |
| WO-2015015519-A1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-02-05 | — | — | WO | claimed |
| WO-2014188211-A1 | HETEROCYCLIC DERIVATES | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2014-11-27 | — | — | WO | claimed |
| EP-3305778-B1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2022-01-19 | — | — | EP | disclosed |
| EP-3305778-A1 | INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2018-04-11 | — | — | EP | disclosed |
| EP-3027605-B1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2017-11-08 | — | — | EP | disclosed |
| EP-3027605-B1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2017-11-08 | — | — | EP | disclosed |
| US-9737510-B2 | Indazole compounds and a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-08-22 | — | — | US | disclosed |
| EP-3027605-A1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2016-06-08 | — | — | EP | disclosed |
| US-20160108036-A1 | HETEROCYCLIC DERIVATES | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-04-21 | — | — | US | disclosed |
| EP-2999697-A1 | HETEROCYCLIC DERIVATES | Kalvista Pharmaceuticals Limited (GB) | 2016-03-30 | — | — | EP | disclosed |
| WO-2015015519-A1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-02-05 | — | — | WO | disclosed |
| WO-2015015519-A1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-02-05 | — | — | WO | disclosed |
| WO-2014188211-A1 | HETEROCYCLIC DERIVATES | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2014-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185759-A1 | NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | GPR119, INSR, CYP11B1 | JAK2 1061/4885JAK1 602/4885ROCK1 799/4885 |
| US-20160108036-A1 | HETEROCYCLIC DERIVATES | BDKRB1, KLKB1, BDKRB2 | JAK2 1553/4885JAK1 2035/4885ROCK1 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.